377953

2-Chloro-1,3,2-dioxaphospholane 2-oxide

• Sinónimos: 2-Chloro-2-oxo-1,3,2-dioxaphospholane, Ethylene glycol chlorophosphate
• Fórmula empírica (notación de Hill): C₂H₄ClO₃P
• Número de CAS: 6609-64-9
• Peso molecular: 142.48
• Beilstein: 606582
• Número CE: 229-560-6
• Número MDL: MFCD00043138
• Código UNSPSC: 12352100
• ID de la sustancia en PubChem: 24863533
• NACRES: NA.22

Propiedades

• Formulario: liquid
• impurezas: <10% 2-Chloro-1,3,2-dioxaphospholane
• índice de refracción: n20/D 1.45 (lit.)
• bp: 89-91 °C/0.8 mmHg (lit.)
• mp: 12-14 °C (neat) (lit.)
• densidad: 1.55 g/mL at 25 °C (lit.)
• temp. de almacenamiento: −20°C
• cadena SMILES: ClP1(=O)OCCO1
• InChI: 1S/C2H4ClO3P/c3-7(4)5-1-2-6-7/h1-2H2
• Clave InChI: SBMUNILHNJLMBF-UHFFFAOYSA-N

Descripción

Descripción general

2-Chloro-1,3,2-dioxaphospholane 2-oxide (COP) is a cyclic chlorophosphate reagent that can be prepared from 2-chloro-1,3,2-dioxaphospholane by reacting with molecular oxygen .

2-Chloro-1,3,2-dioxaphospholane 2-oxide is used in esterification reactions for cyclic phosphate synthesis, also reacts with phenyl grignard reagents.

Aplicación

2-Chloro-1,3,2-dioxaphospholane 2-oxide may be used in the synthesis of:

• 2-methacryloyloxyethylphosphorylcholine
• miltefosine (hexadecylphosphocholine, MT) analogs
• phosphoric acid 2-trimethylamino-ethyl ester undec-10-enyl ester
• uridine nucleolipid, (2′,3′-O-16-hentriacontanyliden-uridine-5′-phosphocholine, PUPC)
• adenosine nucleoamphiphile, (2′,3′-O-16-hentriacontanyliden-adenosine-5′-phosphocholine, PAPC)
• structurally related phospholipids which are either conformationally restricted or flexible
• phosphatidylcholines

Reactant for:

• Synthesis of amino-functionalized hybrid hydrocarbon/fluorocarbon double-chain phospholipid
• Synthesis of UV-polymerizable lipids via Chabrier reaction
• Syntheses of block copolymers of poly(aliphatic ester) with clickable polyphosphoester
• Imprinting molecular recognition sites on multiwalled carbon nanotubes surface for electrochemical detection of insulin in real samples
• Synthesis of a zwitterionic silane
• Synthesis of a core-shell-corona micelle stabilized by reversible cross-linkage for intracellular drug delivery

Información de seguridad

• Pictogramas: GHS05
• Palabra de señalización: Danger
• Frases de peligro: H314
• Consejos de prudencia: P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363 - P405
• Clasificaciones de peligro: Eye Dam. 1 - Skin Corr. 1B
• Riesgos supl.: EUH014,EUH029
• Código de clase de almacenamiento: 8A - Combustible corrosive hazardous materials
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): >235.4 °F - closed cup
• Punto de inflamabilidad (°C): > 113 °C - closed cup
• Equipo de protección personal: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter