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Merck

142077

Sigma-Aldrich

2,2,2-Trichloroethyl chloroformate

98%

Sinónimos:

2,2,2-Trichloroethoxycarbonyl chloride

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About This Item

Fórmula lineal:
ClCOOCH2CCl3
Número de CAS:
Peso molecular:
211.86
Beilstein:
970619
Número CE:
Número MDL:
Código UNSPSC:
12352100
ID de la sustancia en PubChem:
NACRES:
NA.22
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presión de vapor

0.06 psi ( 20 °C)

Nivel de calidad

Ensayo

98%

Formulario

liquid

índice de refracción

n20/D 1.471 (lit.)

bp

171-172 °C (lit.)

densidad

1.539 g/mL at 25 °C (lit.)

grupo funcional

chloro

temp. de almacenamiento

2-8°C

cadena SMILES

ClC(=O)OCC(Cl)(Cl)Cl

InChI

1S/C3H2Cl4O2/c4-2(8)9-1-3(5,6)7/h1H2

Clave InChI

LJCZNYWLQZZIOS-UHFFFAOYSA-N

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Descripción general

2,2,2-Trichloroethyl chloroformate (TrocCl) serves as a versatile reagent used for selective acylation and dealkylation in organic synthesis. It is used in regio, chemo, and stereoselective synthesis.[1]

Aplicación

  • 2,2,2-Trichloroethyl chloroformate was used as derivatizing reagent in gas chromatographic/mass spectrometric determination of a large range of amphetamine-related drugs and ephedrines in plasma, urine and hair samples[2].
  • It was used as starting reagent during the synthesis of 6-Nor-9,10-dihydrolysergic acid methyl ester[3].
  • It was used as reagent during N-demethylation of dextromethorphan[4].
  • It was used as protecting reagent for aliphatic and aromatic hydroxyl and amino groups[5].
Protecting reagent for aliphatic and aromatic hydroxyl and amino groups.[5]

Pictogramas

Skull and crossbonesCorrosion

Palabra de señalización

Danger

Frases de peligro

Clasificaciones de peligro

Acute Tox. 3 Inhalation - Eye Dam. 1 - Skin Corr. 1B

Código de clase de almacenamiento

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter


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A Dasgupta et al.
American journal of clinical pathology, 109(5), 527-532 (1998-05-12)
Amphetamine and methamphetamine are commonly abused central nervous system stimulants. We describe a rapid new derivatization of amphetamine and methamphetamine using 2,2,2-trichloroethyl chloroformate for gas chromatography-mass spectrometric analysis. Amphetamine and methamphetamine, along with N-propyl amphetamine (internal standard), were extracted from
A M Crider et al.
Journal of pharmaceutical sciences, 70(12), 1319-1321 (1981-12-01)
6-Nor-9,10-dihydrolysergic acid methyl ester (IV) was prepared by demethylation of 9,10-dihydrolysergic acid methyl ester (II) with 2,2,2-trichloroethyl chloroformate, followed by reduction of the intermediate carbamate (III) with zinc in acetic acid. The 6-ethyl-V and 6-n-propyl-VI derivatives were prepared by alkylation
2, 2, 2-Trichloroethyl Chloroformate (TrocCl)
EO dos Reis, et al.
Synlett, 2007, 1473-1474 (2007)
A simplified method for the gas chromatographic determination of pethidine and norpethidine after derivatization with trichloroethyl chloroformate.
P Hartvig et al.
Journal of chromatography, 274, 355-360 (1983-05-13)
Giampietro Frison et al.
Rapid communications in mass spectrometry : RCM, 19(7), 919-927 (2005-03-05)
A new analytical approach, based on derivatization with 2,2,2-trichloroethyl chloroformate and gas chromatography/mass spectrometry (GC/MS), was investigated for qualitative and quantitative analyses of a large range of amphetamine-related drugs and ephedrines in plasma, urine and hair samples. Sample preparation involved

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    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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