The solution stability of this product has not been determined internally. Various sources state that solutions in DMSO or DMF may be stored at -20° for up to 3 months. The solution stability should be determined by the end-user.
W102
(R)-(+)-WIN 55,212-2 mesylate salt
≥98% (HPLC), powder, CB2 agonist
Synonyme(s) :
WIN552122 mesylate
Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
About This Item
Formule linéaire :
C27H26N2O3 · CH3SO3H
Numéro CAS:
Poids moléculaire :
522.61
Numéro MDL:
Code UNSPSC :
12352200
ID de substance PubChem :
Nomenclature NACRES :
NA.77
Le tarif et la disponibilité ne sont pas disponibles actuellement.
Produits recommandés
Nom du produit
(R)-(+)-WIN 55,212-2 mesylate salt, ≥98% (HPLC)
Niveau de qualité
Essai
≥98% (HPLC)
Forme
powder
Contrôle du médicament
regulated under CDSA - not available from Sigma-Aldrich Canada
Couleur
white to beige
Solubilité
0.1 M HCl: 0.25 mg/mL
DMSO: 12 mg/mL
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 2.4 mg/mL
0.1 M NaOH: insoluble
H2O: insoluble
Chaîne SMILES
CS(O)(=O)=O.Cc1c(C(=O)c2cccc3ccccc23)c4cccc5OC[C@@H](CN6CCOCC6)n1c45
InChI
1S/C27H26N2O3.CH4O3S/c1-18-25(27(30)22-9-4-7-19-6-2-3-8-21(19)22)23-10-5-11-24-26(23)29(18)20(17-32-24)16-28-12-14-31-15-13-28;1-5(2,3)4/h2-11,20H,12-17H2,1H3;1H3,(H,2,3,4)/t20-;/m1./s1
Clé InChI
FSGCSTPOPBJYSX-VEIFNGETSA-N
Informations sur le gène
human ... CNR1(1268) , CNR2(1269)
Description générale
WIN 55,212-2 is a member of the aminoalkylindole class of compounds.[1]
Application
(R)-(+)-WIN 55,212-2 mesylate salt has been used as a high affinity cannabinoid agonist for intraperitoneal injection into rats to induce behavioural sensitization.[2] It has also been used as a synthetic cannabinoid drug and cannabinoid receptor 1 (CNR1) agonist to treat Becn2+/− mice and wild-type (WT) littermate to analyze the levels of CNR1 in the brain.[3]
Actions biochimiques/physiologiques
It is known to decrease the lipopolysaccharide mediated release of tumor necrosis factor- α and interleukin-1 in mice.[1]
Caractéristiques et avantages
This compound is featured on the Cannabinoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Notes préparatoires
The solubility of this chemical in DMF has not been determined. However, various sources state this chemical can be solubilized in about 30 mg/ml of DMF.
Informations légales
Sold with the permission of Sterling-Winthrop, Inc.
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
Eyeshields, Gloves, type N95 (US)
Faites votre choix parmi les versions les plus récentes :
Certificats d'analyse (COA)
Lot/Batch Number
Vous ne trouvez pas la bonne version ?
Si vous avez besoin d'une version particulière, vous pouvez rechercher un certificat spécifique par le numéro de lot.
Déjà en possession de ce produit ?
Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Les clients ont également consulté
Rational design and synthesis of an orally active indolopyridone as a novel conformationally constrained cannabinoid ligand possessing antiinflammatory properties
Wrobleski ST, et al.
Journal of Medicinal Chemistry, 46(11), 2110-2116 (2003)
Dual Role of PPAR-c in Induction and Expression of Behavioral Sensitization to Cannabinoid Receptor Agonist WIN55,212-2
Enayatfard L, et al.
Neuromolecular Medicine, 15, 523-535 (2013)
U Herzberg et al.
Neuroscience letters, 221(2-3), 157-160 (1997-01-17)
The effects of a high affinity cannabinoid receptor agonist were evaluated in rats subjected to chronic constriction injury of the sciatic nerve (CCI) or a sham operation. Intraperitoneal (i.p.) injections of the active, but not the inactive enantiomer, alleviated the
Autophagy activation by novel inducers prevents BECN2-mediated drug tolerance to cannabinoids
Kuramoto K, et al.
Autophagy, 12(9), 1460-1471 (2016)
X Pan et al.
Molecular pharmacology, 49(4), 707-714 (1996-04-01)
Modulation of neuronal ion channels by the cloned rat brain CB1 cannabinoid receptor was investigated with the use of a heterologous neuronal expression system. Transient expression of the rat brain CB1 cannabinoid receptor was accomplished through microinjection of in vitro
-
Once reconstituted, at what temperature should it be kept?
1 answer-
Helpful?
-
-
Can WIN be dissolved in Dimethylformamide (DMF) to achieve a concentration of 10 mM?
1 answer-
The solubility of this chemical in DMF has not been officially determined. Nevertheless, according to various sources, this chemical can be solubilized in approximately 30 mg/ml of DMF.
Helpful?
-
-
Hello, How should this product be stored (what temperature ?). Thanks in advance.
1 answer-
This product is to be stored in room temperature.
Helpful?
-
-
Is WIN dissolvable in Dimethylformamide (DMF) in a concentration of 10 mM?
1 answer-
The solubility of this chemical in DMF has not been determined. However, various sources state this chemical can be solubilized in about 30 mg/ml of DMF.
Helpful?
-
Active Filters
Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..
Contacter notre Service technique
