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U7257

Sigma-Aldrich

Urotensin II human

≥97% (HPLC), synthetic

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About This Item

Formule empirique (notation de Hill):
C64H85N13O18S2
Numéro CAS:
251293-28-4
Poids moléculaire :
1388.57
Numéro MDL:
MFCD04115626
Code UNSPSC :
12352200
ID de substance PubChem :
329827647
Nomenclature NACRES :
NA.32

Source biologique

synthetic

Niveau de qualité

200

Pureté

≥97% (HPLC)

Forme

lyophilized powder

Technique(s)

calcium flux assay: suitable

Numéro d'accès UniProt

O95399

Température de stockage

−20°C

Chaîne SMILES 

CC(C)[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@@H](N)CCC(O)=O)[C@@H](C)O)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](Cc4c[nH]c5ccccc45)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc6ccc(O)cc6)C(=O)N1)C(O)=O

InChI

1S/C64H85N13O18S2/c1-33(2)52(64(94)95)75-61(91)48-32-97-96-31-47(73-59(89)46(29-51(82)83)72-62(92)49-17-11-25-77(49)63(93)53(34(3)78)76-54(84)40(66)22-23-50(80)81)60(90)70-43(26-35-12-5-4-6-13-35)56(86)71-45(28-37-30-67-41-15-8-7-14-39(37)41)58(88)68-42(16-9-10-24-65)55(85)69-44(57(87)74-48)27-36-18-20-38(79)21-19-36/h4-8,12-15,18-21,30,33-34,40,42-49,52-53,67,78-79H,9-11,16-17,22-29,31-32,65-66H2,1-3H3,(H,68,88)(H,69,85)(H,70,90)(H,71,86)(H,72,92)(H,73,89)(H,74,87)(H,75,91)(H,76,84)(H,80,81)(H,82,83)(H,94,95)/t34-,40+,42+,43+,44+,45+,46+,47+,48+,49+,52+,53+/m1/s1

Clé InChI

HFNHAPQMXICKCF-USJMABIRSA-N

Informations sur le gène

human ... UTS2(10911)

Amino Acid Sequence

Glu-Thr-Pro-Asp-Cys-Phe-Trp-Lys-Tyr-Cys-Val [Disulfide Bridge: 5-10]

Application

Urotensin II human was used in agonist and antagonist preparation for calcium mobilization assay. The product can also be used as a test compound for studying the impact of dihydropyridine calcium antagonist amlodipine in human internal mammary artery and clinical implications.

Actions biochimiques/physiologiques

A neuroendocrine peptide of the CRF family that was originally isolated from fish brain but is also found in mammalian brain and spinal motor neurons. It is a potent vasoconstrictor. It may be a mediator of stress-induced anorexia.
Human urotensin II is a vasoactive neuropeptide that belongs to CRF family and stimulates arterial smooth muscle contraction, actin stress fiber formation and proliferation via small GTPase RhoA and there downstream effector Rho-kinase activation.The product is also a selective and potent vasoconstrictor agent as well as an agonist for the orphan receptor GPR14.

Autres remarques

Lyophilized from 0.1% TFA in H2O

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

V Sauzeau et al.
Circulation research, 88(11), 1102-1104 (2001-06-09)
The aim of this work was to investigate the coupling of human urotensin II (hU-II) to RhoA activation and regulation of RhoA-dependent functions. The use of the Rho-kinase inhibitor Y-27632 and the development of a membrane-permeant RhoA inhibitor (TAT-C3) allowed
Xiao-Yan Bai et al.
The Annals of thoracic surgery, 92(2), 610-616 (2011-06-28)
Graft spasm in the internal mammary artery (IMA) may occur after coronary artery bypass grafting (CABG). We investigated the effect of human urotensin II (hU-II), a cyclic peptide hormone present in human blood and tissues, and the effect of vasodilators
Xiao-Yan Bai et al.
The Annals of thoracic surgery, 90(6), 1952-1957 (2010-11-26)
Graft spasm remains challenging in CABG (coronary artery bypass grafting) surgery. We investigated the inhibitory effect of a dihydropyridine calcium antagonist amlodipine on the vasoconstriction mediated by potassium chloride (KCl), human urotensin-II (hU-II), and U46619 in human internal mammary artery
Hong Xin et al.
Journal of biomolecular screening, 12(5), 705-714 (2007-06-01)
The no-wash calcium assay kits developed by Molecular Devices Corporation have greatly enhanced the throughput of cell-based calcium mobilization high-throughput screening (HTS) assays and enabled screening using nonadherent cells. The fluorescent imaging plate reader (FLIPR) Calcium 3 Assay Kit, optimal
R S Ames et al.
Nature, 401(6750), 282-286 (1999-09-28)
Urotensin-II (U-II) is a vasoactive 'somatostatin-like' cyclic peptide which was originally isolated from fish spinal cords, and which has recently been cloned from man. Here we describe the identification of an orphan human G-protein-coupled receptor homologous to rat GPR14 and

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