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T8761

Sigma-Aldrich

Tyloxapol

nonionic surfactant

Synonyme(s) :

4-(1,1,3,3-Tetramethylbutyl)phenol polymer with formaldehyde and oxirane

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About This Item

Numéro CAS:
25301-02-4
Numéro MDL:
MFCD00149002
Code UNSPSC :
12161900
ID de substance PubChem :
24900557
Nomenclature NACRES :
NA.25

Niveau de qualité

200

CMC

0.018 mM

Température de transition

cloud point 94.3 °C

Chaîne SMILES 

[H]C([H])=O.OCCO.CC(C)(C)CC(C)(C)c1ccc(O)cc1

InChI

1S/C14H22O.C2H6O2.CH2O/c1-13(2,3)10-14(4,5)11-6-8-12(15)9-7-11;3-1-2-4;1-2/h6-9,15H,10H2,1-5H3;3-4H,1-2H2;1H2

Clé InChI

GWJOFBXSBDVUMH-UHFFFAOYSA-N

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Description générale

A nonionic liquid polymer of the alkyl aryl polyether alcohol type. Used as a surfactant.

Application

Tyloxapol is a nonionic liquid polymer of the alkyl aryl polyether alcohol type. It is used as a surfactant to aid liquefaction. Tyloxapol is used in the development of non-ionic surfactant-based liposomes (niosomes) for use in drug delivery systems. Tyloxapol may be used to study its mechanism of protecting macrophages from endotoxins. Tyloxapol may be used to study is potential cell toxicitiy.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H315,H319,H335

Classification des risques

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

235.4 °F - closed cup

Point d'éclair (°C)

113 °C - closed cup

Équipement de protection individuelle

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

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Jung-hua Steven Kuo et al.
Pharmaceutical research, 23(7), 1509-1516 (2006-06-17)
Tyloxapol, a viscous polymer of the alkyl aryl polyether alcohol type, is classified as a nonionic surfactant and is widely used in biomedical applications. Although tyloxapol has been reported to be cytotoxic in various cell lines, there is no published
Jung-Hua Steven Kuo et al.
Colloids and surfaces. B, Biointerfaces, 64(2), 208-215 (2008-03-14)
Tyloxapol is reported to prevent macrophages from reacting to endotoxin. However, the intracellular responses that tyloxapol induces in macrophages are still not fully explored. Hence, the objective of this study was to evaluate the intracellular events in macrophages treated with
Tariq Al-Qirim et al.
Archiv der Pharmazie, 345(5), 401-406 (2012-01-24)
A new series of N-(benzoylphenyl) and N-(acetylphenyl)-1-benzofuran-2-carboxamides (3a-3d and 4a'-4c') were synthesized. Compounds (3a, 3b, and 4a'-4c') were tested in vivo using Triton-WR-1339-induced hyperlipidemic rats as an experimental model for their hypolipidemic activity. The tested animals were divided into eight
M Saravanan et al.
Pharmaceutical biology, 49(10), 1074-1081 (2011-05-20)
Ichnocarpus frutescens (L.) R.Br. (Apocynaceae) is used to treat diabetes and hyperlipidemia in folk medicine. The crude methanol extract and fractions of I. frutescens were investigated for antihyperlipidemic effect. Fresh leaves of I. frutescens were extracted with methanol and fractionated
S K Mehta et al.
Colloids and surfaces. B, Biointerfaces, 101, 434-441 (2012-09-27)
The present study delineates the formulation of niosomes from biocompatible surfactant Tyloxapol and their potential as drug delivery system for anti-tuberculosis drugs. Drug loaded niosomes have a size of 150 nm with a loading efficiency of 97.95±0.2, 98.89±0.2 and 99.50±0.2%
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