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T3251

Sigma-Aldrich

(±)-α-Tocophérol

synthetic, ≥96% (HPLC)

Synonyme(s) :

DL-tout-rac-α-Tocophérol, Vitamine E

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About This Item

Formule empirique (notation de Hill):
C29H50O2
Numéro CAS:
10191-41-0
Poids moléculaire :
430.71
Beilstein:
94012
Numéro CE :
233-466-0
Numéro MDL:
MFCD00006848
Code UNSPSC :
12352205
eCl@ss :
34058016
ID de substance PubChem :
24900118
Nomenclature NACRES :
NA.77
Le tarif et la disponibilité ne sont pas disponibles actuellement.

Source biologique

synthetic

Niveau de qualité

200

Essai

≥96% (HPLC)

Forme

liquid

Technique(s)

HPLC: suitable

Couleur

faint brown to brown
 yellow to very dark yellow

Solubilité

H2O: insoluble
acetone: miscible
chloroform: miscible
ethanol: miscible
vegetable oils: miscible

Densité

0.950 g/mL at 20 °C (lit.)

Température de stockage

2-8°C

Chaîne SMILES 

CC(C)CCCC(C)CCCC(C)CCCC1(C)CCc2c(C)c(O)c(C)c(C)c2O1

InChI

1S/C29H50O2/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(30)23(5)24(6)28(26)31-29/h20-22,30H,9-19H2,1-8H3

Clé InChI

GVJHHUAWPYXKBD-UHFFFAOYSA-N

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Application

(±)-α-Tocopherol has been used for preparing mycobacterial emulsions. It has also been used to study its immunomodulatory effect on influenza virus.

Actions biochimiques/physiologiques

Tocopherols (vitamin E) comprise of a series (α, β, γ and δ) of chiral compounds that differ by the methylation degree of the phenol moiety of the chromanol ring. They function as lipid soluble antioxidants and protect cell membranes from oxidative damage. α-tocopherols are favorably absorbed by humans and their nicotinate salts can function as vitamin E supplements. Studies have also reported that vitamin E can prevent cell damage caused by pharmacologically induced epilepsy in rats.

Notes préparatoires

(±)-α-Tocopherol is miscible with chloroform, ethanol, ether, acetone, and vegetable oils. However, it is practically insoluble in water. (±)-α-Tocopherol is unstable under alkaline conditions.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H317

Classification des risques

Skin Sens. 1

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Équipement de protection individuelle

Eyeshields, Gloves

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Certificats d'analyse (COA)

Lot/Batch Number
0000415404
0000415404
MKCX1479
0000370394
0000342827

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

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Les clients ont également consulté

Slide 1 of 8

1 of 8

(±)-α-Tocophérol European Pharmacopoeia (EP) Reference Standard

T1550000

(±)-α-Tocophérol

(+)-α-Tocopherol Type VI, from vegetable oil, liquid (≥0.88M based on potency, density and molecular wt.), BioReagent, suitable for insect cell culture, ≥1000 IU/g

Sigma-Aldrich

T1539

(+)-α-Tocopherol

(+)-α-Tocopherol acetate oil or semi-solid, ~1360 IU/g

Sigma-Aldrich

T3001

(+)-α-Tocopherol acetate

δ-Tocopherol analytical standard

Supelco

47784

δ-Tocopherol

alpha-Tocophérol United States Pharmacopeia (USP) Reference Standard

USP

1667600

alpha-Tocophérol

Vitamine E water-miscible 1 ml = 500 mg DL-a-tocopherol acetate for oral use, EMPROVE® ESSENTIAL, USP

SAFC

5.00862

Vitamine E

(+)-γ-Tocopherol analytical standard

Supelco

47785

(+)-γ-Tocopherol

(±)-α-Tocophérol 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Supelco

V-020

(±)-α-Tocophérol

M Tagami et al.
Laboratory investigation; a journal of technical methods and pathology, 78(11), 1415-1429 (1998-12-05)
Cerebral ischemia followed by oxygen reperfusion induces apoptosis in hippocampal neurons in stroke-prone spontaneously hypertensive rats (SHRSP) but not in Wistar Kyoto rats (WKY). The overproduction of oxygen-free radicals that occurs in the tissues of SHRSP is implicated in reoxygenation
Thomas H Sanderson et al.
Molecular and cellular neurosciences, 64, 116-122 (2015-01-13)
Cellular mechanisms involved in multiple neurodegenerative diseases converge on mitochondria to induce overproduction of reactive oxygen species, damage to mitochondria, and subsequent cytochrome c release. Little is currently known regarding the contribution mitochondrial dynamics play in cytochrome c release following
Ida Johansson et al.
Autophagy, 11(9), 1636-1651 (2015-08-04)
Accumulation and aggregation of misfolded proteins is a hallmark of several diseases collectively known as proteinopathies. Autophagy has a cytoprotective role in diseases associated with protein aggregates. Age-related macular degeneration (AMD) is the most common neurodegenerative eye disease that evokes
Farhan Basit et al.
Cell death & disease, 8(3), e2716-e2716 (2017-03-31)
Inhibition of complex I (CI) of the mitochondrial respiratory chain by BAY 87-2243 ('BAY') triggers death of BRAFV600E melanoma cell lines and inhibits in vivo tumor growth. Here we studied the mechanism by which this inhibition induces melanoma cell death.
Marina G Yefimova et al.
Autophagy, 9(5), 653-666 (2013-02-27)
Phagocytosis and autophagy are typically dedicated to degradation of substrates of extrinsic and intrinsic origins respectively. Although overlaps between phagocytosis and autophagy were reported, the use of autophagy for ingested substrate degradation by nonprofessional phagocytes has not been described. Blood-separated
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Questions

1–5 of 5 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. What is the concentration of item T3251 (W/V)?

    1 answer

    1. The material is a neat or pure liquid, undiluted with a solvent. At a purity of 100%, the molarity is 2.205 M. The minimum purity specification for this product is 96%. The molarity will vary from lot to lot based on the determined purity. For a lot of this product with a minimum purity of 96%, the molarity will be 2.117 M.

      Helpful?

  4. Hi. Could you please provide the concentration of this product (w/v)? Thanks!

    1 answer

    1. This material is a neat or pure liquid that has not been diluted with a solvent. At a purity of 100%, the molarity is 2.205 M. The minimum purity specification for this product is 96%. The molarity will change from lot to lot based on the determined purity. A lot of this product with a minimum purity of 96% will be 2.117 M. Please see the link below to review a sample or lot specific Certificate of Analysis:
      https://www.sigmaaldrich.com/product/sigma/t3251#product-documentation

      Helpful?

  5. Hi, I would like to ask if you have the LC-MS grade of this chemical (Tocopherol CAS number; 10191-41-0, part no: T3251-5G). I'm in need of the LC-MS authentic standard of this chemical to compare my isolated compound with. Thank you.

    1 answer

    1. This product is not considered a standard nor has it been tested for use as such in LC-MS. Product number V-020 is a 1 mg/mL α-tocopherol solution in methanol. This product is a certified reference material suitable for use as a standard in HPLC or LC-MS/MS.

      Please see the link below to review this product option:
      https://www.sigmaaldrich.com/product/cerillian/v020

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