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Key Documents

SAB4502195

Sigma-Aldrich

Anti-PI3-kinase p85-α antibody produced in rabbit

affinity isolated antibody

Synonyme(s) :

GRB1, P85A, PI3-kinase p85-α subunit, PI3K, PI3K p85-α

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About This Item

Numéro MDL:
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen 83 kDa

Espèces réactives

mouse, rat, human

Concentration

~1 mg/mL

Technique(s)

ELISA: 1:1000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

Numéro d'accès NCBI

Numéro d'accès UniProt

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... PIK3R1(5295)

Catégories apparentées

Description générale

Anti-PI3-kinase p85-α antibody detects endogenous levels of total PI3-kinase p85-α protein.
The PIK3R1 (phosphoinositide-3-kinase regulatory subunit 1) gene is mapped to human chromosome 5q13.1. It encodes for p85α regulatory subunit.

Immunogène

The antiserum was produced against synthesized peptide derived from human PI3-kinase p85-alpha/gamma.

Immunogen Range: 436-485

Application

Anti-PI3-kinase p85-α antibody produced in rabbit has been used in western blotting.

Actions biochimiques/physiologiques

PIK3R1 (phosphoinositide-3-kinase regulatory subunit 1) is known to mediate immune cell differentiation, development and function. Dominant mutations of PIK3R1 causes hyperactivation of the PI3K signaling pathway, leading to immunodeficiency and also SHORT syndrome (short stature, hyperextensibility, hernia, ocular depression, Rieger anomaly, and teething delay). PI3K is an important part of insulin and growth factor signaling. PIK3R1 gene is considered to be intolerant to functional variation among the human population. In human, downregulation of PIK3R1 is observed in many types of cancer. PIK3R1 is regarded as a tumor suppressor gene. PIK3R1 mediates tumorigenesis and malignant progression. The gene harbors receptor tyrosine kinases activity and participates in the activation of class IA PI3Ks.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

nwg

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


Certificats d'analyse (COA)

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Aberrant low expression of p85? in stromal fibroblasts promotes breast cancer cell metastasis through exosome-mediated paracrine Wnt10b.
Chen Y
Oncogene, 36(33), 4692-4705 (2017)
Qiong Wu et al.
Cell death & disease, 9(2), 232-232 (2018-02-16)
G-protein-coupled receptor (GPCR)-related proteins are dysregulated and the GPCR CC-chemokine receptor 10 (CCR10) is significantly upregulated in inflammation-driven HCC. However, CCR10's role in inflammation-driven hepatocarcinogenesis remains unknown. The aim of this study was to evaluate the role of CCR10 in
?-Arrestin1 enhances hepatocellular carcinogenesis through inflammation-mediated Akt signalling.
Yang Y
Nature Communications, 6:7369 (2015)
Oncogenic mutations in GNAQ occur early in uveal melanoma.
Onken MD
Investigative Ophthalmology & Visual Science, 49(12), 5230-5234 (2008)
Dominant Splice Site Mutations in PIK3R1 Cause Hyper IgM Syndrome, Lymphadenopathy and Short Stature.
Petrovski S
Journal of clinical immunology, 36(5), 462-471 (2016)

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