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Key Documents

SAB4500433

Sigma-Aldrich

Anti-Claudin 4 antibody produced in rabbit

affinity isolated antibody

Synonyme(s) :

CLD4, CLDN4, CPE- receptor, Claudin-4, Clostridium perfringens enterotoxin receptor

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen 22 kDa

Espèces réactives

rat, mouse, human

Concentration

~1 mg/mL

Technique(s)

ELISA: 1:5000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

Numéro d'accès NCBI

O14493

Numéro d'accès UniProt

O14493

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... CLDN4(1364)

Catégories apparentées

Description générale

The CLDN4 (claudin 4) gene is mapped to human chromosome 7q11.23. The encoded protein is an integral member, localized to tight junction. It is also expressed in the epithelial basolateral membrane.

Immunogène

The antiserum was produced against synthesized peptide derived from human Claudin 4.

Immunogen Range: 160-209

Actions biochimiques/physiologiques

CLDN4 (claudin 4) is associated with epithelial differentiation, and is widely implicated in carcinomas. Its expression is considered to differentiate carcinoma with that of sarcoma. Claudin 4 expression is implicated in gastric cancer induced by Helicobacter pylori infection. It contributes to invasion, metastasis and prognosis of the disease. The CLDN4 gene is known to be overexpressed in a number of chemoresistant and metastatic cancer. Its localization to the tight junction prevents paracellular diffusion. Along with this, the extracellular loop interaction mediated by claudin 4 with the neighbouring cells makes it a differentiation marker.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

nwg

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Claudin-4 expression distinguishes SWI/SNF complex-deficient undifferentiated carcinomas from sarcomas
Schaefer IM, et al.
Modern Pathology, 30(4), 539-539 (2017)
Claudin-1,-3 and-4 proteins and mRNA expression in benign and malignant breast lesions: a research study
Thokes AM, et al.
Breast Cancer Research, 7(2), R296-R296 (2005)
Claudin-4 activity in ovarian tumor cell apoptosis resistance and migration
Hicks DA, et al.
BMC Cancer, 16(1), 788-788 (2016)
Role of TGF-beta-induced Claudin-4 expression through c-Jun signaling in non-small cell lung cancer
Rachakonda G, et al.
Cellular Signalling, 28(10), 1537-1544 (2016)
TLR2 activation induced by H. pylori LPS promotes the differential expression of claudin-4, -6, -7 and -9 via either STAT3 and ERK1/2 in AGS cells
Chavarria-Velazquez CO, et al.
Immunobiology, 223(1), 38-48 (2018)

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