S1129

Succinyl coenzyme A sodium salt

≥85%

• Synonyme(s) : Succinyl CoA sodium salt
• Formule empirique (notation de Hill): C₂₅H₄₀N₇O₁₉P₃S
• Numéro CAS: 108347-97-3
• Poids moléculaire : 867.61
• Code UNSPSC : 41106305
• ID de substance PubChem : 24899460
• Nomenclature NACRES : NA.51

Propriétés

• Niveau de qualité: 200
• Essai: ≥85%
• Forme: powder
• Solubilité: water: 50 mg/mL, clear, colorless
• Température de stockage: −20°C
• Chaîne SMILES: [Na+].[Na+].CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)([O-])=O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC([O-])=O
• InChI: 1S/C25H40N7O19P3S/c1-25(2,20(38)23(39)28-6-5-14(33)27-7-8-55-16(36)4-3-15(34)35)10-48-54(45,46)51-53(43,44)47-9-13-19(50-52(40,41)42)18(37)24(49-13)32-12-31-17-21(26)29-11-30-22(17)32/h11-13,18-20,24,37-38H,3-10H2,1-2H3,(H,27,33)(H,28,39)(H,34,35)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-2/t13-,18-,19-,20?,24-/m1/s1
• Clé InChI: VNOYUJKHFWYWIR-FZEDXVDRSA-L

Description

Application

Succinyl coenzyme A sodium salt has been used:

• for the nonenzymatic succinylation of lysine in vitro[1],
• as a substrate for adipic acid biosynthesis in recombinant E. coli [2]
• in isocitrate dehydrogenase (ICDH) treatment for the succinylation of proteins[3]
• as a substrate to study the specificity and kinetics of enzymes such as acetate:succinate CoA-transferase and 5-aminolevulinate synthase (ALA synthase)

Actions biochimiques/physiologiques

Succinyl CoA is an intermediate in the citric acid cycle.[4] It is formed by α-ketoglutarate dehydrogenase by the decarboxylation of α-ketoglutarate. Succinyl CoA is also formed from propionyl CoA during the β-oxidation of odd-chain fatty acids.[5] Succinyl CoA serves as a precursor in heme synthesis. It is also required for the oxidation of ketone bodies.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H315,H319,H335
• Conseils de prudence: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves