Q3625

Quinidine

sodium channel blocker

• Formule empirique (notation de Hill) : C₂₀H₂₄N₂O₂
• Numéro CAS: 56-54-2
• Poids moléculaire : 324.42
• Beilstein: 91866
• Numéro CE : 200-279-0
• Numéro MDL: MFCD00135581
• Code UNSPSC : 12352200
• ID de substance PubChem : 24899331
• Nomenclature NACRES : NA.77

Propriétés

• Nom du produit: Quinidine, anhydrous
• Qualité: anhydrous
• Impuretés: ≤20% Dihydroquinidine (according to USP specifications., actual content given on label)
• Pf: 168-172 °C (lit.)
• Auteur: Bayer
• Chaîne SMILES: COc1ccc2nccc([C@H](O)C3CC4CCN3C[C@@H]4C=C)c2c1
• InChI: 1S/C20H24N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3/t13-,14-,19+,20-/m0/s1
• Clé InChI: LOUPRKONTZGTKE-LHHVKLHASA-N
• Informations sur le gène: human ... ABCB1(5243) , CYP2D6(1565) , CYP3A4(1576) , KCNH1(3756) , SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335) ; mouse ... Abcb1a(18671) , Abcb1b(18669) ; rat ... Cyp2d1(266684) , Cyp2d2(25053) , Cyp2d3(24303) , Cyp2d4v1(171522)

Description

Application

Quinidine has been used:

• as an inhibitor of cytochrome P450 enzyme isoform CYP2D6[1]
• as a potassium (K⁺) channel blocker in microglia[2]
• to test its effect on electrophysiological behaviour of human induced pluripotent stem cells (hiPSC) cardiomyocytes[3]

Actions biochimiques/physiologiques

Class IA antiarrhythmic; potassium channel blocker.

Quinidine, an isomer of quinine has potential side effects like proarrhythmia on usage. It prolongs cardiac potential and is sodium channel blocker.[4] It is a potential antagonist for α1-adrenoceptors and contributes to hypotension.[5] It inhibits cytochrome P450 2D6 and improves circulation and brain penetration of dementia drug, dextromethorphan.[6] Quinidine-dextromethorphan combination may be useful in treating pseudobulbar affect (PBA).[7]

Caractéristiques et avantages

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Pictogrammes: GHS06
• Mention d'avertissement: Danger
• Mentions de danger: H301,H317
• Conseils de prudence: P261 - P264 - P272 - P280 - P301 + P310 - P302 + P352
• Classification des risques: Acute Tox. 3 Oral - Skin Sens. 1
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 1
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Faceshields, Gloves