Stock solutions of this product may be stored at 0 - 4 C for the short term (days to weeks), or -20 C for long term (months).
Q3251
Quinacrine dihydrochloride
≥90% (TLC), powder, MAO-A/B inhibitor
Synonyme(s) :
6-Chloro-9-(4-diethylamino-1-methylbutylamino)-2-methoxyacridine dihydrochloride, Atebrin dihydrochloride, Mepacrine dihydrochloride
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About This Item
Formule empirique (notation de Hill):
C23H30ClN3O · 2HCl
Numéro CAS:
Poids moléculaire :
472.88
Beilstein:
4834013
Numéro CE :
Numéro MDL:
Code UNSPSC :
12352101
ID de substance PubChem :
Nomenclature NACRES :
NA.77
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Produits recommandés
Nom du produit
Quinacrine dihydrochloride, ≥90%
Source biologique
synthetic
Niveau de qualité
Essai
≥90%
Forme
powder
Pf
257 °C
Solubilité
H2O: soluble, clear to hazy
Auteur
Bayer
Chaîne SMILES
Cl[H].Cl[H].CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc3ccc(OC)cc13
InChI
1S/C23H30ClN3O.2ClH/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23;;/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26);2*1H
Clé InChI
UDKVBVICMUEIKS-UHFFFAOYSA-N
Informations sur le gène
human ... MAOA(4128) , MAOB(4129)
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Description générale
Quinacrine is an acridine derivative and a potent antimalarial agent.[1]
Application
Actions biochimiques/physiologiques
Non-selective MAO-A/B inhibitor.
Quinacrine has anthelmintic functionality and used in the female sterilization. It is used to treat systemic lupus erythematosus and rheumatic diseases.[1] Apart from malaria, Quinacrine is effective for treating giardia and tapeworm infections.[5] It inhibits nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity in addition to monoamine oxidase inhibition.[6]
Caractéristiques et avantages
This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Stockage et stabilité
Stock solutions are stable for up to 60 h at 20°C.
Autres remarques
This product is not assigned an expiration date or recommended retest date.
Mention d'avertissement
Warning
Mentions de danger
Conseils de prudence
Classification des risques
Acute Tox. 4 Oral
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Équipement de protection individuelle
dust mask type N95 (US), Eyeshields, Gloves
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Biophysical Journal, 111(4), 864-874 (2016)
Quinacrine sterilization (QS): time for reconsideration
Lippes J
Contraception, 92(2), 91-95 (2015)
Genotoxic potential of some commonly used antimalarials: A review
Sahu Rand Kashyap P
International Journal of Pharmaceutical Sciences and Research, 3(6), 1569-1569 (2012)
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For how long and in which temperature can we store the product, after reconstitution?
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Is it okay to measure fluorescence by using FACS? (with FITC Fluorochrome)
1 answer-
The suitability of this compound for use in FACS has not been determined. This application would need to be validated by the end user. Please see the link below to a publication that may be helpful:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718257/Helpful?
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How long can it be used after purchasing?
1 answer-
This product is not assigned an expiration date or recommended retest date. Products with no expiration date or recommended retest date should be routinely inspected by customers to ensure they perform as expected. These products are also subject to a one-year warranty from the date of shipment. For more information, you may access the Product Dating Information document under ADDITIONAL USEFUL DOCUMENTS ABOUT OUR PRODUCTS at the bottom of the Quality Services page with this link: https://www.sigmaaldrich.com/US/en/life-science/quality-and-regulatory-management/quality-services.
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I’m planning to make stocks for 10mM. What is the storage temperature? Is it same with the product?
1 answer-
Stock solutions are stable for up to 60 h at 20°C.
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What is the storage temperature?
1 answer-
Product Q3251, Quinacrine dihydrochloride, is stored at room temperature.
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Can Product Q3251, Quinacrine dihydrochloride be used for staining platelets?
1 answer-
We have not tested Product Q3251, Quinacrine dihydrochloride for staining platelets. The reference link indicates that platelets can be visualized with the fluorescent dye mepacrine (quinacrine dihydrochloride) at a final concentration of 10 μM. Brian Savage, et al., PNAS, 99 (1): 425-430, (2002).
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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