PZ0191

Crizotinib

≥98% (HPLC)

• Synonyme(s) : (R)-3-[1-(2,6-Dichloro-3-fluoro-phenyl)-ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine, PF 2341066, PF-02341066, PF02341066, Xalkori
• Formule empirique (notation de Hill): C₂₁H₂₂Cl₂FN₅O
• Numéro CAS: 877399-52-5
• Poids moléculaire : 450.34
• Numéro MDL: MFCD12407409
• Code UNSPSC : 12352200
• ID de substance PubChem : 329823765
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥98% (HPLC)
• Forme: powder
• Couleur: white to tan
• Température de stockage: room temp
• Chaîne SMILES: C[C@@H](Oc1cc(cnc1N)-c2cnn(c2)C3CCNCC3)c4c(Cl)ccc(F)c4Cl
• InChI: 1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1
• Clé InChI: KTEIFNKAUNYNJU-GFCCVEGCSA-N
• Informations sur le gène: human ... ALK(238) , MET(4233)

Description

Application

Crizotinib has been used:

• to investigate its effects on hepatocyte growth factor receptor (c-Met) expression, proliferation and apoptosis
• to block neurotrophic tyrosine kinase receptor type 1 (NTRK1) activity in epithelial cells
• to restore sensitivity to erlotinib

Actions biochimiques/physiologiques

Crizotinib (PF-02341066) is an ATP-competitive inhibitor of the receptor tyrosine kinases (RTKs) c-Met (hepatocyte growth factor receptor) and anaplastic lymphoma kinase (ALK). Crizotinib is a highly specific inhibitor of c-Met and ALK among > 120 different RTKs surveyed. Crizotinib was approved for treatment of a subtype of nonsmall-cell lung cancer (NSCLC) with ALK fusion mutations.

Caractéristiques et avantages

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Informations légales

Sold for research purposes under agreement from Pfizer Inc.

Informations sur la sécurité

• Pictogrammes: GHS08,GHS07,GHS09
• Mention d'avertissement: Warning
• Mentions de danger: H317,H319,H341,H400
• Conseils de prudence: P202 - P273 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Classification des risques: Aquatic Acute 1 - Eye Irrit. 2 - Muta. 2 - Skin Sens. 1
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable