P7412

Pirenzepine dihydrochloride

≥98% (TLC), powder

• Synonyme(s) : 5,11-Dihydro-11-[(4-methyl-1-piperazinyl)acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one dihydrochloride
• Formule empirique (notation de Hill): C₁₉H₂₁N₅O₂ · 2HCl
• Numéro CAS: 29868-97-1
• Poids moléculaire : 424.32
• Numéro CE : 249-907-5
• Numéro MDL: MFCD00055214
• Code UNSPSC : 12352200
• ID de substance PubChem : 24277863
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 200
• Essai: ≥98% (TLC)
• Forme: powder
• Couleur: white to light yellow
• Solubilité: H₂O: 50 mg/mL
• Chaîne SMILES: Cl[H].Cl[H].CN1CCN(CC1)CC(=O)N2c3ccccc3C(=O)Nc4cccnc24
• InChI: 1S/C19H21N5O2.2ClH/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24;;/h2-8H,9-13H2,1H3,(H,21,26);2*1H
• Clé InChI: FFNMBRCFFADNAO-UHFFFAOYSA-N
• Informations sur le gène: human ... CHRM1(1128)

Description

Description générale

Pirenzepine dihydrochloride is an anticholinergic agent.[1][2] It is also considered as an antiulcer drug.[3] It is used to treat myopia, gastric and duodenal ulcers.[1][4] Pirenzepine dihydrochloride induces the dimerization of muscarinic M1 receptors.[5]

Application

Pirenzepine dihydrochloride has been used

• in transactivation of fibroblast growth factor receptor (FGFR).[6]
• as a supplement in cell culture.[7]
• for the stimulation of human fibroblasts[8]

Actions biochimiques/physiologiques

Selective M₁ muscarinic acetylcholine receptor antagonist.

Caractéristiques et avantages

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This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Attention

Hygroscopic; store desiccated at room temperature.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)