P7265

Prostaglandin A₁

≥98% (HPLC), powder, NF-κB inhibitor

• Synonyme(s) : (13E,15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid, PGA₁
• Formule empirique (notation de Hill): C₂₀H₃₂O₄
• Numéro CAS: 14152-28-4
• Poids moléculaire : 336.47
• Numéro Beilstein : 2003401
• Numéro MDL: MFCD00077858
• Code UNSPSC : 12352211
• ID de substance PubChem : 24898834
• Nomenclature NACRES : NA.77

Propriétés

• product name: Prostaglandin A₁, synthetic
• Source biologique: synthetic
• Niveau de qualité: 200
• Pureté: ≥98%
• Forme: powder
• Température de stockage: −20°C
• Chaîne SMILES: O=C1[C@H](CCCCCCC(O)=O)[C@@H](/C=C/[C@H](CCCCC)O)C=C1
• InChI: 1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/b14-12+/t16-,17-,18+/m0/s1
• Clé InChI: BGKHCLZFGPIKKU-LDDQNKHRSA-N

Description

Actions biochimiques/physiologiques

Prostaglandin A1 (PGA1) is a cyclopentenone prostaglandin containing chemically reactive α,β-unsaturated carbonyl. This cyclooxygenase 2 (COX-2) metabolic product aids in regulating the development and progression of Alzheimer′s disease (AD). In addition, PGA1 also regulates various biological processes via Michael addition. It exhibits antiviral activity against avian influenza A viruses (IAV) by inducing cytoprotective heat shock response in infected cells and by inhibiting nuclear factor-κB (NF-κB) activity.

Informations sur la sécurité

• Pictogrammes: GHS08,GHS07
• Mention d'avertissement: Danger
• Mentions de danger: H302,H360F
• Conseils de prudence: P201 - P301 + P312 + P330 - P308 + P313
• Classification des risques: Acute Tox. 4 Oral - Repr. 1B
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)