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P2371

Sigma-Aldrich

Pamidronate disodium salt hydrate

≥95% (NMR), solid

Synonyme(s) :

3-Amino-1-hydroxy-1-phosphonopropanephosphonic acid disodium salt hydrate

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About This Item

Formule empirique (notation de Hill):
C3H9NO7P2Na2 · xH2O
Numéro CAS:
57248-88-1
Poids moléculaire :
279.03 (anhydrous basis)
Numéro CE :
260-647-1
Numéro MDL:
MFCD11045314
Code UNSPSC :
12352200
ID de substance PubChem :
24724574
Nomenclature NACRES :
NA.77
Le tarif et la disponibilité ne sont pas disponibles actuellement.

Niveau de qualité

100

Essai

≥95% (NMR)

Forme

solid

Couleur

white

Pf

300 °C

Solubilité

H2O: 28 mg/mL

Auteur

Novartis

Température de stockage

2-8°C

Chaîne SMILES 

O.[Na+].[Na+].NCCC(O)(P(O)([O-])=O)P(O)([O-])=O

InChI

1S/C3H11NO7P2.2Na.H2O/c4-2-1-3(5,12(6,7)8)13(9,10)11;;;/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11);;;1H2/q;2*+1;/p-2

Clé InChI

TVQNUQCYOOJTMK-UHFFFAOYSA-L

Actions biochimiques/physiologiques

Bone resorption inhibitor; inhibitor of farnesyl diphosphate synthase (IC50 = 200 nM).
Pamidronate disodium has the ability to block Wnt and β-catenin signaling, which modulates the osteogenic differentiation in bone marrow mesenchymal stem cells (BMMSCs).[1] It can also reduce bilirubin-impaired apoptosis and helps to develop dentinogenic dysfunction of stem cells from human deciduous teeth.[2]

Caractéristiques et avantages

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302

Classification des risques

Acute Tox. 4 Oral

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

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Certificats d'analyse (COA)

Lot/Batch Number
0000082881
0000082881
070M4707V
0000143801
0000143801

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Raimund Hirschberg
Current opinion in supportive and palliative care, 6(3), 342-347 (2012-06-20)
More than 10 years ago evidence emerged that bisphosphonate therapy especially in malignant bone diseases is associated with renal complications. The nature of renal injury from bisphosphonates has become clearer in recent years. Pamidronate can rarely cause (collapsing) focal segmental
Yan Wang et al.
PloS one, 7(9), e44868-e44868 (2012-10-03)
It is unclear whether the new anti-catabolic agent denosumab represents a viable alternative to the widely used anti-catabolic agent pamidronate in the treatment of Multiple Myeloma (MM)-induced bone disease. This lack of clarity primarily stems from the lack of sufficient
George Bullock et al.
Materials (Basel, Switzerland), 13(9) (2020-05-07)
Medication-related osteonecrosis of the jaw (MRONJ) is a side effect of bisphosphonate therapy, characterised by exposed necrotic bone. The soft tissues of the oral mucosa no longer provide a protective barrier and MRONJ patients experience pain, infections and difficulties eating.
Evangelos Terpos et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(18), 2347-2357 (2013-05-22)
The aim of the International Myeloma Working Group was to develop practice recommendations for the management of multiple myeloma (MM) -related bone disease. An interdisciplinary panel of clinical experts on MM and myeloma bone disease developed recommendations based on published
Pamidronate decreases bilirubin-impaired cell death and improves dentinogenic dysfunction of stem cells from human deciduous teeth
Yamaza H, et al.
Stem Cell Research & Therapy, 9(1), 303-303 (2018)
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