A4978

Alendronate sodium trihydrate

≥97% (NMR), powder

• Synonyme(s) : 4-amino-1-hydroxy-1-phosphonobutyl phosphonic acid, monosodium, MK-217
• Formule empirique (notation de Hill): C₄H₁₂NaNO₇P₂ · 3 H₂O
• Numéro CAS: 121268-17-5
• Poids moléculaire : 325.12
• Numéro MDL: MFCD01748233
• Code UNSPSC : 41106300
• ID de substance PubChem : 24724391
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥97% (NMR)
• Forme: powder
• Couleur: white
• Solubilité: water, double-distilled: 10 mg/mL
• Température de stockage: −20°C
• Chaîne SMILES: [Na+].[H]O[H].[H]O[H].[H]O[H].NCCCC(O)(P(O)(O)=O)P(O)([O-])=O
• InChI: 1S/C4H13NO7P2.Na.3H2O/c5-3-1-2-4(6,13(7,8)9)14(10,11)12;;;;/h6H,1-3,5H2,(H2,7,8,9)(H2,10,11,12);;3*1H2/q;+1;;;/p-1
• Clé InChI: DCSBSVSZJRSITC-UHFFFAOYSA-M
• Informations sur le gène: human ... FDPS(2224)

Description

Application

Alendronate sodium trihydrate has been used:

• for calcium phosphate nanoparticles (nCaP)/ bisphosphonate (BP) coating on titanium implants and analyze its osteogenic capacity
• in osteogenic differentiation of human bone marrow stromal cells (hBMSCs) isolated from aged osteoporosis patients- and healthy-person
• to treat osteoblast progenitor cells and osteoblasts and study their effect on osteoblast behaviors using conventional assays and simple digital image analysis

Actions biochimiques/physiologiques

Alendronate is a nitrogen-containing bisphosphonate that is known to hinder the mevalonate pathway and limit osteoclastic function and activity. Alendronate sodium trihydrate is a bone resorption inhibitor, farnesyl diphosphate synthase inhibitor, and CD45 protein tyrosine phosphatase inhibitor.

Alendronate sodium trihydrate is a bone resorption inhibitor; farnesyl diphosphate synthase inhibitor (IC₅₀ = 460 nM); CD45 protein tyrosine phosphatase inhibitor.

Stockage et stabilité

Following reconstitution, it is recommended to aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302
• Conseils de prudence: P264 - P270 - P301 + P312 - P501
• Classification des risques: Acute Tox. 4 Oral
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves