O4000

Oxythiamine chloride hydrochloride

≥95% (HPLC)

• Synonyme(s) : 5-(2-Hydroxyethyl)-3-(4-hydroxy-2-methyl-5-pyrimidinylmethyl)-4-methylthiazolium chloride
• Formule empirique (notation de Hill): C₁₂H₁₆ClN₃O₂S · HCl
• Numéro CAS: 614-05-1
• Poids moléculaire : 338.25
• Numéro MDL: MFCD00050656
• Code UNSPSC : 12352116
• ID de substance PubChem : 24897990
• Nomenclature NACRES : NA.79

Propriétés

• Niveau de qualité: 200
• Pureté: ≥95% (HPLC)
• Forme: powder
• Technique(s): HPLC: suitable
• Couleur: white to off-white
• Température de stockage: −20°C
• Chaîne SMILES: CC(N1)=NC=C(C[N+]2=CSC(CCO)=C2C)C1=O.Cl.[Cl-]
• InChI: 1S/C12H16N3O2S.2ClH/c1-8-11(3-4-16)18-7-15(8)6-10-5-13-9(2)14-12(10)17;;/h5,7,16H,3-4,6H2,1-2H3,(H,13,14,17);2*1H
• Clé InChI: QHUYPZVMEJLSEB-UHFFFAOYSA-N

Description

Description générale

Oxythiamine is a thiamine antimetabolite and the source through diet is by consuming acidic thiamine rich foods.

Application

Oxythiamine chloride hydrochloride is suitable for use:

• as a reference standard for calibration curve generation in liquid chromatography-tandem mass spectrometry (LC-MS/MS) for oxythiamine pyrophosphate (OTPP) quantification in red blood cells
• as a thiamine transport inhibitor in human mammary epithelial cells (HMEC) and breast cancer cell lines
• in the synthesis of oxythiamineH picrolonate salt

Actions biochimiques/physiologiques

Oxythiamine (OT) is a thiamine antagonist. It is a transketolase inhibitor and is employed to study anti-metastatic mechanisms, especially those involving metalloproteinases (MMP). It significantly sensitizes human hepatocellular carcinoma cells (HCC) to sorafenib, favoring tumor suppression.

Oxythiamine inhibits Transketolase, the enzyme that controls the nonoxidative branch of the pentose phosphate pathway.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)