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Key Documents

N9150

Sigma-Aldrich

Nystatin

ready made solution, suitable for cell culture

Synonyme(s) :

Nystatin, Fungicidin, Mycostatin

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About This Item

Numéro CAS:
Numéro MDL:
Code UNSPSC :
12352207
Nomenclature NACRES :
NA.76

product name

Nystatin Ready made solution, suitable for cell culture

Source biologique

Streptomyces noursei

Forme

solution

Technique(s)

cell culture | mammalian: suitable

Conditions d'expédition

dry ice

Température de stockage

−20°C

Chaîne SMILES 

O[C@@H]([C@H](C)[C@H](C)O1)[C@@H](C)/C=C/C=C/CC/C=C/C=C/C=C/C=C/[C@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N)[C@@H]2O)C[C@@]3([H])[C@H](C(O)=O)[C@@H](O)C[C@](O)(O3)C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)C[C@@H](O)CC1=O

InChI

1S/C47H75NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-36(53)35(52)20-19-31(49)21-32(50)22-33(51)23-39(55)62-29(3)28(2)42(27)56/h5-6,8,10-18,27-38,40-44,46,49-54,56-58,61H,7,9,19-26,48H2,1-4H3,(H,59,60)/b6-5+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28+,29-,30+,31+,32+,33+,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1

Clé InChI

VQOXZBDYSJBXMA-QEKUPDCNSA-N

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Description générale

Nystatin is a fungistatic and fungicidal polyene antibiotic. It binds to ergosterol which increases cell membrane permeability in sensitive fungi. Nystatin is mainly clinically active against Candida species. However, it is also reported to be effective against Aspergillus, Coccidioides immitis, Cryptococcus neoformans, Histoplasma capsulatum, Blastomyces dermatidis, and other yeasts and fungi. Nystatin has also been used to enrich mutants by negative selection in yeasts. The minimum inhibitory concentration (MIC) of Nystatin to Saccharomyces cerevisiae was reported to be 3μg/ml while for clinical isolates of Candida albicans the MIC was reported to be 4-16μg/ml.

Actions biochimiques/physiologiques

Mode of Action: Nystatin acts by binding to ergosterols in fungal cell membranes, increasing permeability of the membrane, and creating nystatin/ergosterol based ion channels. It also functions as a lipid raft-inhibiting reagent and as membrane associated cholesterol.

Antimicrobial spectrum: Nystatin acts against fungi, yeasts and molds.

Caractéristiques et avantages

  • Nystatin ready made solution is a fully solubilized formulation of Nystatin with potency of 8000-13000 units/ml according to USP standard.
  • Nystatin ready made solution is 0.2μm filtered, endotoxin.
  • The suggested working concentration of Nystatin ready made solution is 30 units/ml.
  • The ready made solution is light sensitive. It is recommended to store the solution in the dark.
  • It is recommended to avoid freeze thaw cycles of this product. Therefore, it is recommended to aliquot and store at -20°C.

Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Antifungal drug susceptibility of Candida albicans
Bii CC, Ouko TT, Amukoye E, Githinji LW
East African Medical Journal, 79(3), 143-145 (2002)
The Biochemical Genetics of Yeast
Fink, G. R.
Enzymologia, 17-A, 59-78 (1970)
Polyene macrolide derivatives. III
Bonner, D. P., Mechlinski, W., and Schaffner, C. P.
The Journal of Antibiotics, 25 (4), 261-262 (1972)
Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Pappas PG, Kauffman CA, Andes DR, et al.
Infectious Diseases, 62, el-50 (2016)
Polyene toxicity in renal medulla: injury mediated by transport activity
Brezis, M., et al.
Science, 224, 66-68 (1984)

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