Yes, this product is known to work with human cells. A relevant citation that may serve as a reference is the following: J Mol Cell Cardiol. 2011 Feb;50(2):346-56. doi: 10.1016/j.yjmcc.2010.09.001. Epub 2010 Sep 15. - "Mesenchymal stem cells stimulate protective genetic reprogramming of injured cardiac ventricular myocytes" PMID: 20837021.
I5271
IL-1β mouse
≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
Synonyme(s) :
IL-1β, Interleukin-1β, Lymphocyte activating factor
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About This Item
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Nom du produit
Interleukin-1β from mouse, IL-1β, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
Source biologique
mouse
Niveau de qualité
Produit recombinant
expressed in E. coli
Essai
≥97% (SDS-PAGE)
Forme
lyophilized powder
Puissance
≤0.010 ng/mL ED50
Qualité
endotoxin tested
Poids mol.
17.5 kDa (containing 153 amino acid residues)
Conditionnement
pkg of 5X5 μg
pkg of 5 μg
Technique(s)
cell culture | mammalian: suitable
Impuretés
≤0.1ng/mg
Numéro d'accès UniProt
Température de stockage
−20°C
Informations sur le gène
mouse ... Il1b(16176)
Description générale
Interleukin-1β (IL-1β) cytokine is generated by monocytes, dendritic cells, macrophages and keratinocytes. Pro-IL-1β, an IL-1β precursor undergoes proteolytic cleavage to produce its active form of 17 kDa.[1]
Application
Interleukin-1β from mouse has been used:
- as a proinflammatory agent,[2] to induce inflammatory signaling cascades mediated cellular damage[3]
- to study its effect on fetuin A-induced inflammatory response in podocyte[4]
- to check its effect on the expression of mitogen-activated protein kinase 4 using 3T3-L1 adipocytes[5]
Actions biochimiques/physiologiques
Interleukin-1β (IL-1β) is a potent inflammatory cytokine,[1] and mediates inflammation through proinflammatory molecules: cyclooxygenase-2 (COX2) and nitric oxide.[6] IL-1β release is stimulated by injury and increased levels are observed in response to severe pain.[7] It has its main function in T-cell activation, antigen recognition and T-helper cell 17 cell development. IL-1β is also responsible for the formation of IL-17 and IL-22 by nature killer T (NKT) cells and NK cells. It is known to induce inflammation in psoriasis and rheumatoid arthritis.[1] IL-1β controls intercellular adhesion molecule-1 expression. It is significantly associated with bone damage and vascular injury.[8]
Forme physique
Lyophilized from 0.2 μm filtered solution in 10mM Sodium Citrate, pH 4.0
Remarque sur l'analyse
The biological activity is measured by the dose-dependent stimulation of murine D10G4.1 cells.
Autres remarques
The two closely related agents, Interleukin-1α (IL-1α) and Interleukin-1β (IL-1β) bind to the same cell surface receptor, elicit nearly identical biological responses and yet share 25% homology in their amino acid sequence.
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
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Articles
Interleukins, released from leukocytes, include IL-1β playing crucial roles in inflammation, immune responses, and anti-tumor immunity.
Interleukins, released from leukocytes, include IL-1β playing crucial roles in inflammation, immune responses, and anti-tumor immunity.
Interleukins, released from leukocytes, include IL-1β playing crucial roles in inflammation, immune responses, and anti-tumor immunity.
Interleukins, released from leukocytes, include IL-1β playing crucial roles in inflammation, immune responses, and anti-tumor immunity.
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Is the I5271 Sigma-Aldrich Interleukin-1β from mouse cross-reactive with human cells and suitable for use in treating human cells?
1 answer-
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