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G0776

Sigma-Aldrich

Disialoganglioside-GD2 from bovine brain

~95%, lyophilized powder, semisynthetic

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About This Item

Numéro CAS:
65988-71-8
Numéro MDL:
MFCD00131133
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.77
Le tarif et la disponibilité ne sont pas disponibles actuellement.

Niveau de qualité

200

Essai

~95%

Forme

lyophilized powder

Température de stockage

−20°C

InChI

1S/C74H134N4O32/c1-4-6-8-10-12-14-16-18-19-21-23-25-27-29-31-33-52(89)78-43(44(84)32-30-28-26-24-22-20-17-15-13-11-9-7-5-2)40-101-69-61(95)60(94)63(50(38-81)104-69)106-70-62(96)67(64(51(39-82)105-70)107-68-55(77-42(3)83)59(93)58(92)49(37-80)103-68)110-74(72(99)100)35-46(86)54(76)66(109-74)57(91)48(88)41-102-73(71(97)98)34-45(85)53(75)65(108-73)56(90)47(87)36-79/h30,32,43-51,53-70,79-82,84-88,90-96H,4-29,31,33-41,75-76H2,1-3H3,(H,77,83)(H,78,89)(H,97,98)(H,99,100)/b32-30+/t43?,44?,45-,46-,47?,48?,49-,50-,51-,53+,54+,55-,56?,57?,58+,59-,60-,61-,62-,63-,64+,65+,66+,67-,68+,69-,70+,73-,74+/m1/s1

Clé InChI

FFILOTSTFMXQJC-QCFYAKGBSA-N

Amino Acid Sequence

Cer-Glc-Gal(NeuAc-NeuAc)-GalNAc

Description générale

Disialoganglioside GD2 is a cell surface-associated glycosphingolipid, which comprises sialic acid moiety[1] and is regarded as a carbohydrate antigen.[2]. It is expressed in the skin melanocytes, central and peripheral nervous system.[1]
Gangliosides are major constituents of neuronal cell membranes and endoplasmic reticulum; contain a sialated polysaccharide chain linked to ceramide through a β-glycosidic linkage; for classification of gangliosides see Svennerholm, L., et al. (eds.), Structure and Function of Gangliosides, New York, Plenum, 1980.

Application

Disialoganglioside-GD2 from bovine brain has been used:
  • in the ganglioside- enzyme-linked immunosorbent assay (ELISA)[3]
  • in capture ELISA with anti-GD2 antibody (ch14.18)[4]
  • as a control to test its effect on reactivating autophagy in primary fibroblasts[5]

Actions biochimiques/physiologiques

Disialoganglioside GD2 is expressed in neuroblastoma, melanoma and small cell lung cancer.[2] It is an immunotherapeutic target[2] and is also regarded as a tumor-associated antigen.[6] GD2 may favor cell migrationin tumors by promoting cell growth, as well as extracellular matrix component attachment.[7]

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number
0000242359
0000242359
0000113336
0000106938
066M4082V

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Consulter la Bibliothèque de documents

A E Druĭ et al.
Voprosy onkologii, 58(4), 514-520 (2012-01-01)
The bone marrow (BM) TH, ELAVL4 and GD2 genes expression was evaluated in 331 samples from 57 different stage neuroblastoma (NB) patients, 26 BM samples from patients without NB and samples from 2 NB cell lines (IMR-32, Kelly) by real-time
Wenyong Tong et al.
Methods in molecular biology (Clifton, N.J.), 928, 39-52 (2012-09-08)
Ganglioside GD2 is a cell surface glycosphingolipid that is targeted clinically for cancer diagnosis, prognosis, and therapy. The conformations of free GD2 and of GD2 bound to anti-GD2 mAb 3F8 were resolved by saturation transfer difference nuclear magnetic resonance and
Jan Müller et al.
PloS one, 11(10), e0163648-e0163648 (2016-10-08)
Neuroectodermal tumours are characterized by aberrant processing of disialogangliosides concomitant with high expression of GD2 or GD3 on cell surfaces. Antibodies targeting GD2 are already in clinical use for therapy of neuroblastoma, a solid tumour of early childhood. Here, we
Marie Vincent et al.
International journal of cancer, 133(3), 757-765 (2013-01-29)
Immunocytokines (ICKs) targeting cytokines to the tumor environment using antibodies directed against a tumor-associated antigen often have a higher therapeutic index than the corresponding unconjugated cytokines. Various ICKs displaying significant antitumoral effects in several murine tumor models have already been
S L Pichla et al.
Journal of structural biology, 119(1), 6-16 (1997-06-01)
The GD2 ganglioside is a cell-surface component that appears on the surface of metastatic melanoma cells and is a marker for the progression of the disease. The ME36.1 monoclonal antibody binds to the GD2 ganglioside and has shown potential as
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