D3897

2′-Deoxycytidine

≥99% (HPLC)

• Synonyme(s) : Cytosine deoxyriboside
• Formule empirique (notation de Hill): C₉H₁₃N₃O₄
• Numéro CAS: 951-77-9
• Poids moléculaire : 227.22
• Numéro Beilstein : 87567
• Numéro CE : 213-454-1
• Numéro MDL: MFCD00006547
• Code UNSPSC : 41106305
• ID de substance PubChem : 24893793
• Nomenclature NACRES : NA.51

Propriétés

• Source biologique: synthetic (organic)
• Pureté: ≥99% (HPLC)
• Forme: powder
• Solubilité: water: 50 mg/mL, clear, colorless to very faintly yellow
• Température de stockage: −20°C
• Chaîne SMILES: NC1=NC(=O)N(C=C1)[C@H]2C[C@H](O)[C@@H](CO)O2
• InChI: 1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1
• Clé InChI: CKTSBUTUHBMZGZ-SHYZEUOFSA-N

Description

Description générale

2′-Deoxycytidine (deoxyC) is one of the deoxynucleosides containing cytosine as the nucleobase. It is found in the blood, feces, and urine.

Application

2′-Deoxycytidine has been used:

• as a substrate for Trypanosoma brucei cytidine deaminase (TbCDA) to measure its activity
• as a standard in the isolation and quantification of metabolite levels in murine tumor interstitial fluid by liquid chromatography-mass spectrometry (LC–MS)
• to study the role of autophagy in response to oncogenes and DNA replication stress

Actions biochimiques/physiologiques

2′-Deoxycytidine (deoxyC) forms dCTP upon phosphorylation which is used to synthesis DNA via various DNA polymerases or reverse transcriptases. DeoxyC is the substrate for deoxycytidine deaminase (EC 3.5.4.14) which converts it into 2′-deoxyuridine. DeoxyC is phosphorylated to the nucleotide dCMP by the enzyme deoxycytidine kinase (DCK). DeoxyC serves as a potential head and neck cancer marker.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)