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80198

Sigma-Aldrich

Methoxatin disodium salt

≥97.0% (HPLC)

Synonyme(s) :

PQQ, Pyrrolo-quinoline-quinone disodium salt

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About This Item

Formule empirique (notation de Hill):
C14H4N2Na2O8
Numéro CAS:
122628-50-6
Poids moléculaire :
374.17
Numéro MDL:
MFCD00151711
Code UNSPSC :
12352005
ID de substance PubChem :
329768729
Nomenclature NACRES :
NA.79

Source biologique

fermentation/recombinant

Niveau de qualité

100

Pureté

≥97.0% (HPLC)

Forme

powder

Couleur

red-brown to deep orange
 red-brown to deep red-brown

Température de stockage

2-8°C

Chaîne SMILES 

OC(=O)c1cc(nc2C(=O)C(=O)c3cc([nH]c3-c12)C(=O)O[Na])C(=O)O[Na]

InChI

1S/C14H6N2O8.2Na/c17-10-4-2-6(14(23)24)15-8(4)7-3(12(19)20)1-5(13(21)22)16-9(7)11(10)18;;/h1-2,15H,(H,19,20)(H,21,22)(H,23,24);;/q;2*+1/p-2

Clé InChI

UFVBOGYDCJNLPM-UHFFFAOYSA-L

Description générale

Methoxatin/pyrroloquinoline quinone (PQQ) is mostly seen in plants, few bacteria and single cell eukaryotes, like yeast. It is mainly obtained from methylotrophic bacteria. PQQ may also present in the tissues of mammals.

Application


  • Safety assessment of a novel, dietary pyrroloquinoline quinone disodium salt (mnemoPQQ): This study investigates the safety profile of Methoxatin disodium salt, which has implications for its application in assay development for clinical and diagnostic purposes. Specifically, it addresses the compound′s use in dietary supplements and potential crossover into clinical assays where safety and toxicity are paramount (Shiojima et al., 2022).


Actions biochimiques/physiologiques

In bacteria, pyrroloquinoline quinone (PQQ) is used as a redox cycling cofactor. It acts as a cofactor (prosthetic group) for enzyme-catalyzed redox reactions of glucose and methanol dehydrogenase(s). PQQ is used in liposomes to establish a simple homogeneous assay for the detection of membrane permeabilization by antimicrobial peptides and synthetic copolymers. In bovine plasma amine oxidase, methoxatin may acts as the cofactor.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Evidence for methoxatin (pyrroloquinolinequinone) as the cofactor in bovine plasma amine oxidase from resonance Raman spectroscopy
Moog RS, et al.
Proceedings of the National Academy of Sciences of the USA, 83(22), 8435-8439 (1986)
Xing-Qin Zhou et al.
Scientific reports, 8(1), 8894-8894 (2018-06-13)
Oxidative stress is known to be associated with various age-related diseases. D-galactose (D-gal) has been considered a senescent model which induces oxidative stress response resulting in memory dysfunction. Pyrroloquinoline quinone (PQQ) is a redox cofactor which is found in various
Chee-Hoe Ng et al.
Neurobiology of aging, 55, 33-37 (2017-04-14)
Despite intensive research, the etiology of Parkinson's disease (PD) remains poorly understood and the disease remains incurable. However, compelling evidence gathered over decades of research strongly support a role for mitochondrial dysfunction in PD pathogenesis. Related to this, PGC-1α, a
Mohamed Alburaki et al.
PloS one, 10(5), e0125790-e0125790 (2015-05-21)
Thirty-two honeybee (Apis mellifera) colonies were studied in order to detect and measure potential in vivo effects of neonicotinoid pesticides used in cornfields (Zea mays spp) on honeybee health. Honeybee colonies were randomly split on four different agricultural cornfield areas
Lingbo Kong et al.
PloS one, 8(4), e61013-e61013 (2013-04-25)
The effects of pyrroloquinoline quinine (PQQ) on RANKL-induced osteoclast differentiation and on wear particle-induced osteolysis were examined in this study. PQQ inhibited RANKL-mediated osteoclast differentiation in bone marrow macrophages (BMMs) in a dose-dependent manner without any evidence of cytotoxicity. The
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