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15721

Sigma-Aldrich

Polydatin

≥95% (HPLC)

Synonyme(s) :

Piceid, Reservatrol-3-β-mono-D-glucoside, Resveratrol 3-O-β-D-glucopyranoside

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About This Item

Formule empirique (notation de Hill):
C20H22O8
Numéro CAS:
65914-17-2
Poids moléculaire :
390.38
Numéro Beilstein :
54837
Code UNSPSC :
12352201
ID de substance PubChem :
329750984
Nomenclature NACRES :
NA.25

Pureté

≥95% (HPLC)

Forme

powder

Activité optique

[α]1/D -66.0±2.0° in ethanol

Composition

carbon, 60.5-62.5%

Température de stockage

2-8°C

Chaîne SMILES 

OCC1O[C@@H](Oc2cc(O)cc(\C=C\c3ccc(O)cc3)c2)[C@H](O)[C@@H](O)[C@@H]1O

InChI

1S/C20H22O8/c21-10-16-17(24)18(25)19(26)20(28-16)27-15-8-12(7-14(23)9-15)2-1-11-3-5-13(22)6-4-11/h1-9,16-26H,10H2/b2-1+/t16?,17-,18+,19-,20-/m1/s1

Clé InChI

HSTZMXCBWJGKHG-AEGFYQLOSA-N

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Application

Polydatin, a type of polyphenolic phytoalexin, has many physiological and pharmacological effects including anti-inflammatory and anti-oxidative activities. Polydatin is an effective candidate drug for the protection of photo-inflammation. Polydatin exhibits therapeutic potential for vascular dementia, most likely due to its anti-oxidant activity and the direct protection of neurons.

Actions biochimiques/physiologiques

Stilbene found in medicinal herbs. Antioxidant, anti-inflammatory and neuroprotective.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Pinostilbene hydrate ≥95% (HPLC)

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SML0098

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Emodin 8-glucoside ≥95% (LC/MS-UV)

Sigma-Aldrich

SMB00546

Emodin 8-glucoside

Physcion ≥98.0% (TLC)

Sigma-Aldrich

17797

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4-Bromo-Resveratrol ≥98% (HPLC)

Sigma-Aldrich

SML1078

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Resvératrol United States Pharmacopeia (USP) Reference Standard

USP

1602105

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ε-Viniferin phyproof® Reference Substance

PHL83550

ε-Viniferin

Jianxin Deng et al.
Journal of molecular and cellular cardiology, 53(5), 646-656 (2012-08-28)
Polydatin (PD), a resveratrol glucoside, has recently been suggested to have cardioprotective effects against heart diseases, including ischemia-reperfusion injury and pressure-overload induced ventricular remodeling. However, the mechanisms are poorly understood. This study aims to investigate the direct effects of PD
Jingming Zhang et al.
Molecular medicine reports, 6(4), 815-820 (2012-08-04)
The pathophysiology of non-alcoholic fatty liver disease remains incompletely elucidated, and available treatments are not entirely satisfactory. Polydatin, a stilbenoid compound derived from the rhizome of Polygonum cuspidatum, has been recognised to possess hepatoprotective and anti-inflammatory activities. The purpose of
Hyunsu Park et al.
Journal of agricultural and food chemistry, 60(33), 8183-8189 (2012-07-25)
Piceid is widely used in food, cosmetics, and pharmaceuticals because of its therapeutic benefits. However, the use of piceid as a drug is limited because of its low solubility. To increase solubility, we synthesized piceid glucosides using maltosyltransferase from Caldicellulosiruptor
Xi Xie et al.
Molecular and cellular endocrinology, 362(1-2), 183-193 (2012-06-27)
A number of studies have recently demonstrated the involvement of nuclear factor-kappa B (NF-κB) activation and the subsequent coordinated inflammatory responses in the pathogenesis of diabetic nephropathy (DN). Polydatin has been shown to have the ability of anti-adhesive inflammation. However
M J Wu et al.
International journal of immunopathology and pharmacology, 25(4), 923-934 (2013-01-10)
Fulminant hepatic failure (FHF) is a devastating clinical syndrome with extremely poor prognosis and high mortality. Therefore, better treatment is urgently needed. Polydatin (PD), a traditional anti-inflammatory drug, has been described to protect against liver injury induced by certain hepatotoxins.
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