PHR1854

Candesartan Cilexetil

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonyme(s) : Candesartan cilexetil, 2-ethoxy-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1H-Benzimidazole-7-carboxylic acid 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester, TCV 116, TCY 116
• Formule empirique (notation de Hill): C₃₃H₃₄N₆O₆
• Numéro CAS: 145040-37-5
• Poids moléculaire : 610.66
• Numéro MDL: MFCD00871371
• Code UNSPSC : 41116107
• Nomenclature NACRES : NA.24

Propriétés

• Qualité: certified reference material; pharmaceutical secondary standard
• Niveau de qualité: 300
• Agence: traceable to Ph. Eur. Y0001388; traceable to USP 1087803
• Famille d'API: candesartan
• Forme: powder
• Conditionnement: pkg of 200 mg
• Application(s): pharmaceutical
• Chaîne SMILES: CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc4ccc(cc4)-c5ccccc5-c6nnn[nH]6
• InChI: 1S/C33H34N6O6/c1-3-42-32-34-28-15-9-14-27(31(40)43-21(2)44-33(41)45-24-10-5-4-6-11-24)29(28)39(32)20-22-16-18-23(19-17-22)25-12-7-8-13-26(25)30-35-37-38-36-30/h7-9,12-19,21,24H,3-6,10-11,20H2,1-2H3,(H,35,36,37,38)
• Clé InChI: GHOSNRCGJFBJIB-UHFFFAOYSA-N
• Informations sur le gène: human ... AGTR1(185)

Description

Description générale

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Candesartan cilexetil is an angiotensin II receptor antagonist used as a prodrug in the treatment of hypertension.

Application

This pharmaceutical secondary standard can also be used as follows:

• Determination of candesartan cilexetil in tablet formulations by a UV/fluorescence spectrophotometric method
• Study of the release of candesartan cilexetil in tablet form by reversed-phase high-performance liquid chromatography (RP-HPLC)
• Simultaneous estimation of candesartan cilexetil and hydrochlorothiazide in pharmaceutical preparations using liquid chromatography in combination with photodiode array detector (DAD) and evaporative light scattering detector (ELSD)
• Spectroflourimetric determination of four angiotensin II receptor antagonists (AIIRA’s) in their pure form as well as pharmaceutical formulations

Actions biochimiques/physiologiques

Candesartan cilexetil is the prodrug form of the potent angiotensin II receptor antagonist, candesartan. The prodrug is cleaved by esterases within the intestine to liberate the active molecule.

Remarque sur l'analyse

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Note de bas de page

To see an example of a Certificate of Analysis for this material enter LRAB8504 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Produits recommandés

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Informations sur la sécurité

• Pictogrammes: GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H360D,H373
• Conseils de prudence: P202 - P260 - P280 - P308 + P313 - P405 - P501
• Classification des risques: Repr. 1B - STOT RE 2 Oral
• Organes cibles: Kidney,Blood
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable