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Sigma-Aldrich

Héparine sodium salt from porcine intestinal mucosa

endotoxin, free

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About This Item

Numéro CAS:
9041-08-1
Numéro MDL:
MFCD00081689
Code UNSPSC :
12352201
Nomenclature NACRES :
NA.21

Source biologique

Porcine intestinal mucosa

Niveau de qualité

200

Forme

powder

Utilisation

sufficient for 5 mL blood anticoagulant

Conditionnement

preweighed vial of 300 USP units

Impuretés

endotoxin, free

Couleur

beige

Solubilité

water: soluble 50 g/L
acetone: insoluble
alcohol: insoluble
benzene: insoluble
chloroform: insoluble
diethyl ether: insoluble

Compatibilité

for use with E-Toxate™

Température de stockage

room temp

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Application

Heparin sodium salt from porcine intestinal mucosa has been used as a M199 medium supplement used for maintaining human umbilical vein endothelial cells.

Actions biochimiques/physiologiques

Heparin sodium salt is the salt form of heparinic acid and is a polymer classified as a mucopolysaccharide or a glycosoaminoglycan. It is an anticoagulant that produces its major anticoagulant effect by activating antithrombin. Heparin binds to antithrombin III, a naturally occurring plasma protease inhibitor and accelerates significantly the rate at which antithrombin III (AT-III) inhibits coagulation proteases (factor Xa and thrombin). Additionally, it also facilitates the stabilization and regulation of tryptase as an enzymatically active tetramer.

Attention

Not for injection.

Autres remarques

To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Informations légales

E-Toxate is a trademark of Sigma-Aldrich Co. LLC

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number
0000260909
SLCQ6590
SLCK0042
SLCH9269
SLCD9053

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Overexpression of Functional SLC6A3 in Clear Cell Renal Cell Carcinoma.
Jennifer Hansson et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 23(8), 2105-2115 (2016-09-25)
Mechanism of the anticoagulant action of heparin.
I Björk et al.
Molecular and cellular biochemistry, 48(3), 161-182 (1982-10-29)
Nada M S Al-Saffar et al.
British journal of cancer, 119(9), 1118-1128 (2018-11-01)
AKT is commonly overexpressed in tumours and plays an important role in the metabolic reprogramming of cancer. We have used magnetic resonance spectroscopy (MRS) to assess whether inhibition of AKT signalling would result in metabolic changes that could potentially be
D Beeler et al.
The Journal of biological chemistry, 254(8), 2902-2913 (1979-04-25)
Preparations of low molecular weight porcine heparin with an average specific anticoagulant activity of 94 units/mg were fractionated into "active" and "relatively inactive" forms of the mucopolysaccharide of approximately 6000 daltons each. The active fraction was further subdivided into various
L B Schwartz et al.
The Journal of biological chemistry, 261(16), 7372-7379 (1986-06-05)
Tryptase was shown to be stabilized as an enzymatically active tetramer by association with heparin and dissociated to inactive monomers in the absence of heparin at 37 degrees C in physiologic buffer and in plasma. There was a 50% loss
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