490070

Nitric Oxide Synthase, Neuronal Inhibitor I

The Nitric Oxide Synthase, Neuronal Inhibitor I, also referenced under CAS 357965-99-2, controls the biological activity of neuronal Nitric Oxide Synthase. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

• Synonyme(s) : Nitric Oxide Synthase, Neuronal Inhibitor I, (4S)-N-(4-Amino-5[aminoethyl]aminopentyl)-Nʹ-nitroguanidine, TFA
• Formule empirique (notation de Hill): C₈H₂₁N₇O₂ · 3C₂HF₃O₂ · 2H₂O
• Numéro CAS: 357965-99-2
• Poids moléculaire : 625.40
• Numéro MDL: MFCD05865227
• Code UNSPSC : 12352303
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥95% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; desiccated (hygroscopic); protect from light
• Couleur: white to off-white
• Solubilité: water: 1 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: −20°C
• InChI: 1S/C8H21N7O2.3C2HF3O2/c9-3-5-12-6-7(10)2-1-4-13-8(11)14-15(16)17;3*3-2(4,5)1(6)7/h7,12H,1-6,9-10H2,(H3,11,13,14);3*(H,6,7)/t7-;;;/m0.../s1
• Clé InChI: NYWNMNBIORWOSQ-QTPLPEIMSA-N

Description

Description générale

A cell-permeable, potent and highly selective inhibitor of neuronal nitric oxide synthase (nNOS); (K_i = 120 nM). Displays >2500-fold and 320-fold selectivity over eNOS and iNOS, respectively.

A cell-permeable, potent, and highly selective inhibitor of neuronal nitric oxide synthase (nNOS) (K_i = 120 nM). Displays >2,500-fold and 192-fold selectivity over eNOS and iNOS, respectively.

Actions biochimiques/physiologiques

Cell permeable: yes

Primary Target
nNOS

Product does not compete with ATP.

Reversible: no

Target K_i: 120 nM against nNOS

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Standard Handling (A)

Forme physique

Supplied as a dihydrate.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

Hah, J.M., et al. 2001. J. Med. Chem.44, 2667.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable