D-066

Dehydroepiandrosterone-D₅-3-sulfate (DHEAS-D₅) (2,2,3,4,4,-D₅) sodium salt solution

100 μg/mL in methanol (as free sulfate), ampule of 1 mL, certified reference material, Cerilliant^®

• Synonyme(s) : DHEAS-d₅ (2,2,3,4,4,-D₅), Dehydroepiandrosterone-d₅-3-sulfate sodium salt (2,2,3,4,4,-d₅)
• Formule empirique (notation de Hill): C₁₉D₅H₂₂NaO₅S
• Poids moléculaire : 395.50
• Numéro CE : 200-659-6
• Code UNSPSC : 41116107
• Nomenclature NACRES : NA.24

Propriétés

• Qualité: certified reference material
• Forme: liquid
• Caractéristiques: Snap-N-Spike^®/Snap-N-Shoot^®
• Conditionnement: ampule of 1 mL
• Fabricant/nom de marque: Cerilliant^®
• Concentration: 100 μg/mL in methanol (as free sulfate)
• Technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• Application(s): clinical testing
• Format: single component solution
• Température de stockage: −20°C
• Chaîne SMILES: [Na+].[2H]C1([2H])C[C@]2(C)[C@H]3CC[C@@]4(C)[C@@H](CCC4=O)[C@@H]3CC=C2C([2H])([2H])[C@@]1([2H])OS([O-])(=O)=O
• InChI: 1S/C19H28O5S.Na/c1-18-9-7-13(24-25(21,22)23)11-12(18)3-4-14-15-5-6-17(20)19(15,2)10-8-16(14)18;/h3,13-16H,4-11H2,1-2H3,(H,21,22,23);/q;+1/p-1/t13-,14-,15-,16-,18-,19-;/m0./s1/i7D2,11D2,13D;
• Clé InChI: GFJWACFSUSFUOG-SJDCDROSSA-M

Description

Description générale

An internal standard for DHEAS, a metabolite of dehydroepiandrosterone (DHEA). DHEAS levels are measured by LC-MS/MS for determination of excess adrenal activity as observed in adrenal cancer, certain forms of congenital adrenal hyperplasia (CAH), and polycystic ovary syndrome.

Application

• Silk Fibroin Formed Bioadhesive Ophthalmic Gel for Dry Eye Syndrome Treatment: This research utilizes Cyclosporin A′s anti-inflammatory capabilities to formulate a novel ophthalmic gel aimed at treating Dry Eye Syndrome. By integrating Cyclosporin A into a silk fibroin-based gel, the study showcases a new bioadhesive delivery system that optimizes the drug′s ocular bioavailability and prolongs its therapeutic effects, highlighting the versatility of Cyclosporin A in pharmaceutical formulations (Hao T et al., 2024).

Informations légales

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS02,GHS06,GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H225,H301 + H311 + H331,H370
• Conseils de prudence: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• Classification des risques: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Organes cibles: Eyes
• Code de la classe de stockage: 3 - Flammable liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): 49.5 °F - closed cup
• Point d'éclair (°C): 9.7 °C - closed cup