KITALYSIS-CN

KitAlysis^™ High-Throughput Buchwald-Hartwig Amination Reaction Screening Kit-Pack of 4

• Synonyme(s) : Amination Screening Kit, Buchwald-Hartwig Amination
• Code UNSPSC : 12161503
• Nomenclature NACRES : NA.22

Propriétés

• Capacité de réaction: reaction type: Buchwald-Hartwig Amination; reaction type: Buchwald-Hartwig Cross Coupling Reaction; reaction type: Cross Couplings
• Pertinence de la réaction: reagent type: catalyst; core: palladium
• Température de stockage: room temp

Description

Description générale

The KitAlysis^™ High Throughput Buchwald–Hartwig Amination Reaction Screening Kit enables chemists to quickly and efficiently screen Buchwald–Hartwig C–N cross-coupling reaction conditions. Quick identification of optimal conditions allows faster scale-up of the synthetic reaction. All required chemicals come pre-weighed for ease of use. A step-by-step user guide and experimental excel sheets are available for download to facilitate the process.

Application

There are four possible screens that can be run based upon the user’s substrates. Step-by-step user guides and a downloadable experimental excel sheets for each screen is provided in the below hyperlinks.

Two Solvents, Weak Base (Cs₂CO₃)
Download the experimental excel file here
Two Solvents, Strong Base (NaOt-Bu)
Download the experimental excel file here
One Solvent (Dioxane), Two Bases
Download the experimental excel file here
One Solvent (DMAc), Two Bases
Download the experimental excel file here

Each kit contains 4 screening sets that contain the following:
Each customizable screening kit contains

• 12 X 2 pre-weighed catalysts (1 μmol) in individual microvials with magnetic stir bars
• 2 bases (NaOt-Bu and Cs₂CO₃)
• 2 degassed anhydrous solvents (dioxane and DMAc) in ampules
• 2 substrate reaction vials with stir bars
• 1 internal standard
• 4 reaction block replacement films

Monitor reaction progress via TLC-MS by following this protocol

Best when used with KitAlysis Benchtop Inertion Box and 24-well Reaction Block (sold separately).

Caractéristiques et avantages

• Designed and tested by synthetic chemists
• Easily run 24-microscale reaction in parallel
• 10 μmol reactions with 1 μmol catalyst, 3 equiv. base, 0.1 M concentration
• Customizable Excel Template for quick calculations and easy incorporation into electronic laboratory notebooks

Informations légales

KitAlysis is a trademark of Sigma-Aldrich Co. LLC

Composants de kit seuls

• SnapIT Ampule Opener, Regular, for 1-2ml, 5-10ml, 10-15ml ampoules 1 EA

Composants de kit également disponibles séparément

• 900634 N,N-Dimethylacetamide, anhydrous, ZerO₂^®, 99.8% 8 mL
• 900640 1,4-Dioxane, anhydrous, ZerO₂^®, 99.8% 8 mL
• 702706 Sodium tert-butoxide solution, 2 M in THF, ZerO₂^® 4 mL
• 747130 Josiphos SL-J009-1 Pd G3 5 µmol
• 753009 SPhos Pd G2 5 µmol
• 753246 RuPhos Pd G2 5 µmol
• 756482 P(t-Bu)₃ Pd G2 5 µmol
761605 BrettPhos Pd G3, 98% 5 µmol
762229 tBuXPhos Pd G3, 98% 5 µmol
763004 CPhos Pd G3, 95% 5 µmol
763039 XantPhos Pd G3, 95% 5 µmol
763381 XPhos Pd G3, 98%, 1:1 MTBE adduct 5 µmol
792357 MorDalphos Pd G3 5 µmol
804959 DavePhos-Pd-G3, 95% 5 µmol
804967 rac-BINAP-Pd-G3, 95% 5 µmol

Afficher tout (15)

Informations sur la sécurité

• Pictogrammes: GHS02,GHS08,GHS05,GHS07,GHS09
• Mention d'avertissement: Danger
• Mentions de danger: H251,H312 + H332,H314,H335,H336,H350,H360Df,H373,H410
• Conseils de prudence: P235 - P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Classification des risques: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Eye Dam. 1 - Repr. 1B - Self-heat. 1 - Skin Corr. 1B - STOT RE 2 Oral - STOT SE 3
• Organes cibles: Central nervous system, Kidney,Adrenal gland,Testes, Respiratory system
• Risques supp: EUH019
• Code de la classe de stockage: 4.2 - Pyrophoric and self-heating hazardous materials
• Point d'éclair (°F): -4.0 °F - closed cup
• Point d'éclair (°C): -20 °C - closed cup