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860646

Sigma-Aldrich

1-Methyl-DL-tryptophan

97%

Synonyme(s) :

1-Methyl-DL-tryptophan, 1-Methyltryptophan, 2-Amino-3-(1-methyl-1H-indol-3-yl)propanoic acid, 2-Amino-3-(1-methyl-1H-indol-3-yl)propanoicacid, 2-Amino-3-(1-methylindol-3-yl)propanoic acid, DL-1-Methyltryptophan, N′-Methyl-DL-tryptophan

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About This Item

Formule empirique (notation de Hill):
C12H14N2O2
Numéro CAS:
26988-72-7
Poids moléculaire :
218.25
Numéro CE :
248-157-6
Numéro MDL:
MFCD00005803
Code UNSPSC :
12352100
ID de substance PubChem :
24888516
Nomenclature NACRES :
NA.22

Niveau de qualité

100

Pureté

97%

Forme

solid

Pf

250 °C (dec.) (lit.)

Chaîne SMILES 

Cn1cc(CC(N)C(O)=O)c2ccccc12

InChI

1S/C12H14N2O2/c1-14-7-8(6-10(13)12(15)16)9-4-2-3-5-11(9)14/h2-5,7,10H,6,13H2,1H3,(H,15,16)

Clé InChI

ZADWXFSZEAPBJS-UHFFFAOYSA-N

Catégories apparentées

Application

1-Methyl-DL-tryptophan, a competitive inhibitor of indoleamine 2,3 dioxygenase-1 (IDO1), has been used to study inflammation-induced depression in mice and syncytial virus induced bronchiolitis.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Martin Böttcher et al.
Stem cells (Dayton, Ohio), 34(2), 516-521 (2015-10-21)
Mesenchymal stromal cells (MSCs) possess numerous regenerative and immune modulating functions. Transplantation across histocompatibility barriers is feasible due to their hypo-immunogenicity. MSCs have emerged as promising tools for treating graft-versus-host disease following allogeneic stem cell transplantation. It is well established
Qi-Xiang Ye et al.
Experimental and therapeutic medicine, 14(3), 1884-1891 (2017-10-01)
Cytotoxic T-lymphocyte-associated protein 4 immunoglobulin (CTLA4Ig) and anti-cluster of differentiation 154 (anti-CD154) are able to block B7/CD28 and CD40/CD154 co-stimulatory signals in T cells. Additionally, they promote hematopoietic stem cell transplantation (HSCT) in sensitized recipients and are able to induce
Seung-Ha Yang et al.
Experimental & molecular medicine, 41(5), 315-324 (2009-03-25)
Mesenchymal stem cells (MSCs) can inhibit T cell proliferation; however, the underlying mechanisms are not clear. In this study, we investigated the mechanisms of the immunoregulatory activity of MSCs on T cells. Irradiated MSCs co-cultured with either na?ve or pre-activated
Neda Milosavljevic et al.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 23(8), 1040-1050 (2017-05-10)
Mesenchymal stem cells (MSCs) are, due to immunomodulatory characteristics, considered as novel agents in the treatment of immune-mediated acute liver failure. Although it is known that MSCs can regulate activation of T lymphocytes, their capacity to modulate function of neutrophils
Motivational changes that develop in a mouse model of inflammation-induced depression are independent of indoleamine 2, 3 dioxygenase.
Vichaya, Elisabeth G et al.
Neuropsychopharmacology (2018)
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