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38534

Sigma-Aldrich

Polylactic acid

Mw ~60,000

Synonyme(s) :

Poly(2-hydroxypropionic acid)

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About This Item

Numéro CAS:
26100-51-6
Numéro MDL:
MFCD00081867
Code UNSPSC :
12162002
Nomenclature NACRES :
NA.23

Forme

solid

Durée de conservation

limited shelf life, expiry date on the label

Poids mol.

Mn ~30,000
Mw ~60,000

InChI

1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)

Clé InChI

JVTAAEKCZFNVCJ-UHFFFAOYSA-N

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Description générale

Polylactic acid(PLA) is a biodegradable polyester synthesized from lactic acid monomer via ring opening polymerization. Owing to its excellent thermal, mechanical and barrier properties, it is widely used in the field of tissue engineering, drug delivery, and orthopedic devices.

Application

Polylactic acid can be used to prepare tubular scaffolds via the electrospinning method. These scaffolds are applicable in vascular tissue engineering.

It can be used to prepare PLA/polyvinyl alcohol wound dressing membrane through electrospinning and coating method. The coating of PLA improves the mechanical strength of nanofiber and acts as a protective layer to control the release of drug to the wound site.

It can also be used to synthesize free-standing, flexible ultra-thin PLA nanofilms which can act as a matrix for adhesion, spreading, and proliferation of skeletal muscle cells.

Caractéristiques et avantages

  • Biocompatibility
  • Lower toxicity
  • Low cost
  • Better encapsulation

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Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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Poly(D,L-lactide) average Mn 20,000 (NMR), PDI ≤1.3

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Polyglycolide inherent viscosity 1.4dL/g

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457620

Polyglycolide

Poly(L-lactide) viscosity ~2.0 dL/g, 0.1 % (w/v) in chloroform(25 °C)

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Poly(L-lactide)

Poly(L-lactide) viscosity ~4.0 dL/g, 0.1 % (w/v) in chloroform(25 °C)

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Tong Chen et al.
Carbohydrate polymers, 92(2), 1124-1132 (2013-02-13)
Core-shell structured multifunctional nanocarriers (NCs) of ZnO quantum dots-conjugated gold nanoparticles (Au NPs) as core and amphiphilic hyperbranched block copolymer as shell were synthesized for targeted anticancer drug delivery. The amphiphilic hyperbranched block copolymer contained poly(l-lactide) (PLA) inner arm and
Huan Zhou et al.
Materials science & engineering. C, Materials for biological applications, 33(4), 2302-2310 (2013-03-19)
Fibrous bionanocomposites consisting of amorphous magnesium phosphate (AMP) nanospheres and polylactic acid (PLA) were fabricated by electrospinning. There are two important signatures of this paper. First, AMP, as an alternative to well-known calcium phosphate (CaP) materials, is added to PLA
Paul S Rosen et al.
Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995), 34(1), 34-38 (2013-04-05)
This retrospective case series reports on the use of a polylactic acid barrier that was left exposed in the process of socket preparation for the placement of dental implants. A retrospective chart review found 43 patients with 48 extraction sockets
Dah Hee Kim et al.
Carbohydrate polymers, 92(2), 1006-1011 (2013-02-13)
The purpose of this study is to evaluate the rheological and thermal properties of poly(l-lactic acid) (PLA) composites incorporated with microcrystalline cellulose (MCC) and lignin. The MCC/lignin/PLA composites were fabricated through direct melt compounding. In particular, the effect regarding the
G Faludi et al.
Carbohydrate polymers, 92(2), 1767-1775 (2013-02-13)
PLA biocomposites were prepared using three corn cob fractions and a wood fiber as reference. The composites were characterized by tensile testing, scanning electron microscopy (SEM) and polarization optical microscopy (POM). Micromechanical deformation processes were followed by acoustic emission measurements.
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