246263

Indole-4-carboxylic acid

98%

• Synonyme(s) : 4-Carboxyindole
• Formule empirique (notation de Hill): C₉H₇NO₂
• Numéro CAS: 2124-55-2
• Poids moléculaire : 161.16
• Numéro MDL: MFCD00009739
• Code UNSPSC : 12352100
• ID de substance PubChem : 24854799
• Nomenclature NACRES : NA.22

Propriétés

• Pureté: 98%
• Forme: powder
• Pf: 213-214 °C (lit.)
• Chaîne SMILES: OC(=O)c1cccc2[nH]ccc12
• InChI: 1S/C9H7NO2/c11-9(12)7-2-1-3-8-6(7)4-5-10-8/h1-5,10H,(H,11,12)
• Clé InChI: ROGHUJUFCRFUSO-UHFFFAOYSA-N

Description

Application

• Reactant for preparation of substituted indole derivatives as histamine H3 antagonists
• Reactant for preparation of potent and selective inhibitors of human reticulocyte 15-lipoxygenase-1
• Reactant for preparation of inhibitors of Gli1-mediated transcription in Hedgehog pathway
• Reactant for preparation of pyridinyl carboxylates as SARS-CoV 3CL proinhibitors
• Reactant for preparation of substituted bipiperidinylmethyl amides as CCR3 membrane binding ligands
• Reactant for preparation of indole amide hydroxamic acids as potent inhibitors of histone deacetylases
• Reactant for preparation of 2-[[[4′-chloro-[1,1-biphenyl]-4-yl]thio]methyl]-N-hydroxybutanamide derivatives as specific metalloproteinase

tert-butyl esters of indole and pyrrolecarboylic acids are readily prepared by direct treatment with N,N-dimethylformamide di-tert-butyl acetal (Cat. No. 395005).

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H315,H319,H335
• Conseils de prudence: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves