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SAB4200298

Sigma-Aldrich

Anti-Tensin 1 (internal) antibody produced in rabbit

enhanced validation

~1.5 mg/mL, affinity isolated antibody

Synonym(s):

Anti-TNS, Anti-TNS1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 225 kDa (rat)
antigen ~150 kDa (human)

species reactivity

human, rat

enhanced validation

recombinant expression
Learn more about Antibody Enhanced Validation

concentration

~1.5 mg/mL

technique(s)

western blot: 1-2 μg/mL using HEK-293T cells overexpressing human tensin1.
western blot: 1.5-3 μg/mL using lysates of A10 cells

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TNS1(7145)
mouse ... Tns1(21961)
rat ... Tns1(301509)

General description

Tensin 1, also known as TNS1, is a member of tensin protein family. Tensins are multi domain proteins containing homologous C1, protein phosphatases (PTPases), C2, Src homology 2 (SH2) domains and pTyr-binding (PTB) domains. Tensin 1 mRNA is widely expressed in mouse embryo and various human adult tissues and is localized to focal adhesions.

Immunogen

synthetic peptide corresponding to a sequence located in the internal region of human tensin1, conjugated to KLH. The corresponding sequence is identical in rat and mouse tensin1.

Application

Anti-Tensin 1 (internal) antibody produced in rabbit has been used in immunoblotting.

Biochem/physiol Actions

Tensins play an important role in regulating cell shape and motility. Tensin 1 is involved in organizing the actin cytoskeleton and mediating signal transduction. TNS1 is implicated in myofibroblast differentiation. In addition, it also helps myofibroblasts to form nascent fibronectin and collagen matrix.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Tensin 1 is essential for myofibroblast differentiation and extracellular matrix formation
Bernau K, et al.
American Journal of Respiratory Cell and Molecular Biology, 56(4), 465-476 (2017)
Individual domains of Tensin2 exhibit distinct subcellular localizations and migratory effects
Hafizi S, et al.
The International Journal of Biochemistry & Cell Biology, 42(1), 52-61 (2010)
Tensin1 and a previously undocumented family member, tensin2, positively regulate cell migration
Chen H, et al.
Proceedings of the National Academy of Sciences of the USA, 99(2), 733-738 (2002)

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