T4182

Tyrphostin AG 1478

≥98%

• Sinónimos: N-(3-Chlorophenyl)-6,7-dimethoxy-4-quinazolinamine
• Fórmula empírica (notación de Hill): C₁₆H₁₄ClN₃O₂
• Número de CAS: 175178-82-2
• Peso molecular: 315.75
• Número MDL: MFCD00270914
• Código UNSPSC: 51111800
• ID de la sustancia en PubChem: 24278735
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥98%
• Formulario: solid
• solubilidad: 0.1 M HCl: soluble <0.4 mg/mL; DMSO:methanol (1:1): soluble 10 mg/mL, clear, colorless; ethanol: soluble 10 mg/mL; methylene chloride: soluble 10 mg/mL; 0.1 M NaOH: insoluble; 2-hydroxypropyl-β-cyclodextrin: insoluble; H₂O: insoluble
• temp. de almacenamiento: 2-8°C
• cadena SMILES: COc1cc2ncnc(Nc3cccc(Cl)c3)c2cc1OC
• InChI: 1S/C16H14ClN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20)
• Clave InChI: GFNNBHLJANVSQV-UHFFFAOYSA-N
• Información sobre el gen: human ... EGFR(1956) ; mouse ... Egfr(13649)

Descripción

Aplicación

Tyrphostin AG 1478 has been used as epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor to study its effect on desmoid cell mobility in boyden chamber motility assays. It has also been used to inhibit phosphorylation of c-Met by exogenous transforming growth factor α in epidermoid carcinoma cell line A431.

Acciones bioquímicas o fisiológicas

Selective inhibitor of epidermal growth factor receptor protein

Tyrphostin AG 1478 is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor. It contributes to the development of hypomagnesemia and cardiac dysfunction in rats. Tyrphostin AG 1478 acts as a potential therapeutic agent for breast cancer.

Características y beneficios

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the EGFR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Nota de preparación

Tyrphostin AG 1478 dissolves in DMSO:MeOH (1:1) at 10 mg/ml to yield a clear, colorless solution. It is also soluble in methylene chloride (10 mg/ml), ethanol (10 mg/ml) and 0.1 N HCl (less than 0.4 mg/ml). However, it is insoluble in water, 2-hydroxypropyl-β-cyclodextrin, and 0.1 N NaOH.

Otras notas

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)