T1270

Tiamina hydrochloride

BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture

• Sinónimos: Aneurina hydrochloride, Vitamina B₁ hydrochloride
• Fórmula empírica (notación de Hill): C₁₂H₁₇ClN₄OS · HCl
• Número CAS: 67-03-8
• Peso molecular: 337.27
• NACRES: NA.75
• PubChem Substance ID: 24899952
• eCl@ss: 34058006
• UNSPSC Code: 12352207
• EC Number: 200-641-8
• MDL number: MFCD00012780
• Beilstein/REAXYS Number: 3851771

Propiedades

• biological source: synthetic (organic)
• Quality Segment: 200
• product line: BioReagent
• assay: ≥99.0% (HPLC)
• form: powder
• mol wt: M_w 337.27 g/mol
• technique(s): cell culture | insect: suitable, cell culture | mammalian: suitable, cell culture | plant: suitable
• color: white
• mp: 250 °C (dec.) (lit.)
• solubility: H₂O: 50 mg/mL, clear, colorless
• application(s): agriculture
• SMILES string: CC1=NC(N)=C(C[N+]2=CSC(CCO)=C2C)C=N1.Cl.[Cl-]
• InChI: 1S/C12H17N4OS.2ClH/c1-8-11(3-4-17)18-7-16(8)6-10-5-14-9(2)15-12(10)13;;/h5,7,17H,3-4,6H2,1-2H3,(H2,13,14,15);2*1H/q+1;;/p-1
• InChI key: DPJRMOMPQZCRJU-UHFFFAOYSA-M

Descripción

General description

Listen to an Audio Overview
Thiamine or Vitamin B1 is a positively charged and essential constituent for all tissues. It is present at higher levels in skeletal muscles, liver, kidney, heart, and brain. Thiamine is composed of a pyrimidine ring linked to a thiazole ring via a methylene bridge.

Application

Thiamine hydrochloride has been used as a component:

• of the vitamin-concentrated stock solution for the preparation of Hv-Ca medium for culturing Haloferax volcanii
• of the tris-acetate-phosphate (TAP) medium for culturing Chlamydomonas nivalis
• of modified Bold 3N medium for culturing Chlorella minutissima

Biochem/physiol Actions

Thiamine is converted to thiamine diphosphate post-movement into the cellular membranes by thiamine diphosphokinase. Thiamine diphosphate, an active cofactor is essential for the mechanism of many enzymes involved in the citric acid cycle, the glycolytic pathway, the degradation of branched-chain amino acids, and the pentose phosphate pathway. Thiamine is involved in converting food into energy required for functioning the central and peripheral nervous systems. Lower levels of this vitamin are associated with delirium, Wernicke′s encephalopathy, and Wernicke-Korsakoff syndrome. Thiamine hydrochloride is required to support energy metabolism and amino acid synthesis in cultured cells. It is present in many classical and serum-free formulations.

Información de seguridad

• Pictogramas: GHS07
• Palabra de advertencia: Warning
• Códigos de peligro: H319
• Indicaciones de precaución: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Eye Irrit. 2
• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 1
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable
• EPI (equipos de protección individual): Eyeshields, Gloves, type N95 (US)