SRP3327
IL-1 RECEPTOR ANTAGONIST human
Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)
Sinónimos:
ICIL-1RA, IL-1RN, IL-1Ra, IRAP
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About This Item
Código UNSPSC:
12352200
NACRES:
NA.32
Productos recomendados
origen biológico
human
recombinante
expressed in E. coli
Ensayo
≥98% (HPLC)
≥98% (SDS-PAGE)
Formulario
lyophilized
potencia
20-40 ng/mL
mol peso
17.2 kDa
envase
pkg of 100 μg
condiciones de almacenamiento
(Keep container tightly closed in a dry and well-ventilated place)
técnicas
activity assay: suitable
impurezas
endotoxin, tested
color
white to off-white
Nº de acceso UniProt
Condiciones de envío
wet ice
temp. de almacenamiento
−20°C
Información sobre el gen
human ... IL1R1(3554)
Descripción general
Research area: Immunology & cytokines
Interleukin-1 receptor antagonist (IL-1RA) is a naturally occurring inflammatory inhibitor protein. IL-1Ra is produced by corneal epithelial cells, monocytes, neutrophils, macrophages, and fibroblasts. Recombinant human IL-1Ra is a 17.2kDa protein consisting of 153 amino acid residues.
Interleukin-1 receptor antagonist (IL-1RA) is a naturally occurring inflammatory inhibitor protein. IL-1Ra is produced by corneal epithelial cells, monocytes, neutrophils, macrophages, and fibroblasts. Recombinant human IL-1Ra is a 17.2kDa protein consisting of 153 amino acid residues.
Aplicación
Interleukin-1 receptor antagonist (IL-1RA) human has been used:
- to study the role of interleukin (IL)-1β receptor in cell senescence induced by doxorubicin
- to block the IL-1β binding to its receptor
- to understand the role of autocrine interleukin-1β (IL-1β) signaling downstream of cl- in RPS27 modulation
Acciones bioquímicas o fisiológicas
Interleukin-1 receptor antagonist (IL-1RA) inhibits the activity of IL-1α and IL-1β by competitively blocking binding to their type I and type II receptors. Therapeutically, IL-1RA may help in the treatment of sepsis, cachexia, rheumatoid arthritis, chronic myelogenous leukemia, asthma, psoriasis, and inflammatory bowel disease.
Forma física
Lyophilized from 20 mM Tris, pH 8.0.
Reconstitución
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
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Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Los clientes también vieron
Jenaro A Espitia-Corredor et al.
Biochimica et biophysica acta. Molecular basis of disease, 1868(11), 166525-166525 (2022-08-21)
Cardiac fibroblasts (CFs) undergo senescence in reaction to different stressors, leading to a poor prognosis of cardiac disease. Doxorubicin (Doxo) is an antineoplastic drug with strong cardiotoxic effects, which induces IL-1β secretion and thus, triggers a potent pro-inflammatory response. Doxo
The role of cytokines in cancer-related fatigue.
Kurzrock R
Cancer, 92, 1684-1688 (2001)
Exposure of T lymphocytes to leflunomide but not to dexamethasone favors the production by monocytic cells of interleukin-1 receptor antagonist and the tissue-inhibitor of metalloproteinases-1 over that of interleukin-1beta and metalloproteinases.
Deage V
European Cytokine Network, 9, 663-668 (1998)
Association of IL-1a rs17561 and IL-1 RN rs315952 polymorphisms with Tourette syndrome: a family-based study.
He F
International Journal of Clinical and Experimental Pathology, 8, 4182-4185 (2015)
Disruption of interleukin-1? autocrine signaling rescues complex I activity and improves ROS levels in immortalized epithelial cells with impaired cystic fibrosis transmembrane conductance regulator (CFTR) function.
Clauzure M
PLoS ONE, 9, e99257-e99257 (2014)
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