The solubility test points, not upper limits, are as follows:
- DMF: 5 mg/ml
- DMSO: 5 mg/ml
- PBS (pH 7.2) (1:6): 0.1 mg/ml
- Ethanol: 3 mg/ml
SML2480
Mirabegron
≥98% (HPLC), β3-adrenoceptor agonist, powder
Sinónimos:
2-(2-Amino-1,3-thiazol-4-yl)-N-[4-[2-[((2R)-2-hydroxy-2-phenylethyl)amino]ethyl]phenyl]acetamide, 2-Amino-N-[4-[2-[[(2R)-2-hydroxy-2-phenylethyl]amino]ethyl]phenyl]-4-thiazoleacetamide, YM 178, YM178(R)-Mirabegron
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| A ustedes/SKU | Disponibilidad | Precio |
|---|---|---|
5 mg | Comprobar disponibilidad del carrito | $99.100 |
25 mg | Comprobar disponibilidad del carrito | $401.000 |
Acerca de este artículo
Fórmula empírica (notación de Hill):
C21H24N4O2S
Número CAS:
Peso molecular:
396.51
NACRES:
NA.77
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Servicio técnico
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Permítanos ayudarleNombre del producto
Mirabegron, ≥98% (HPLC)
assay
≥98% (HPLC)
form
powder
optical activity
[α]/D -16 to -22°, c = 0.5 in methanol
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
O[C@@H](CNCCC1=CC=C(NC(CC2=CSC(N)=N2)=O)C=C1)C3=CC=CC=C3
InChI
1S/C21H24N4O2S/c22-21-25-18(14-28-21)12-20(27)24-17-8-6-15(7-9-17)10-11-23-13-19(26)16-4-2-1-3-5-16/h1-9,14,19,23,26H,10-13H2,(H2,22,25)(H,24,27)/t19-/m0/s1
InChI key
PBAPPPCECJKMCM-IBGZPJMESA-N
Application
Mirabegron has been used as a β3-adrenergic receptor (β3-AR) agonist in an in vitro experiment to determine whether β3-AR stimulation specifically activates brown adipose tissue (BAT) thermogenesis in humans.
Biochem/physiol Actions
Mirabegron is a non-antimuscarinic orally active drug with the potential to treat patients with overactive bladder (OAB) symptoms. It aids in bladder relaxation by acting on neural control of the storage phase of micturition by targeting β3-AR. Mirabegron is also used to treat neurogenic detrusor overactivity (NDO) in pediatric patients.
Mirabegron is a potent and selective β3-adrenoceptor agonist that activates the β3 adrenergic receptor in the detrusor muscle in the bladder leading to muscle relaxation and an increase in bladder capacity.
potent and selective β3-adrenoceptor agonist
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Este artículo | |||
|---|---|---|---|
| description ≥98% (HPLC) | description CRS, European Pharmacopoeia (EP) Reference Standard | description ≥98% (HPLC) | description ≥98% (HPLC) |
| assay ≥98% (HPLC) | assay - | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| form powder | form - | form powder | form powder |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility DMSO: 2 mg/mL, clear | solubility - | solubility DMSO: 2 mg/mL, clear | solubility DMSO: 20 mg/mL, clear |
| color white to beige | color - | color white to beige | color white to beige |
| optical activity [α]/D -16 to -22°, c = 0.5 in methanol | optical activity - | optical activity - | optical activity - |
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signalword
Warning
hcodes
Hazard Classifications
Repr. 2
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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