SML1791
Urolithin A
≥97% (HPLC), powder, anti-inflammatory
Sinónimos:
3,8-Dihydroxy-6H-benzo[c]chromen-6-one
Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
About This Item
Fórmula empírica (notación de Hill):
C13H8O4
Número de CAS:
Peso molecular:
228.20
Número MDL:
Código UNSPSC:
12352200
NACRES:
NA.77
Productos recomendados
Nombre del producto
Urolithin A, ≥97% (HPLC)
Nivel de calidad
Ensayo
≥97% (HPLC)
Formulario
powder
color
white to beige
solubilidad
DMSO: 20 mg/mL, clear
temp. de almacenamiento
2-8°C
cadena SMILES
OC1=CC=C(C(C=CC(O)=C2)=C2C(O3)=O)C3=C1
InChI
1S/C13H8O4/c14-7-1-3-9-10-4-2-8(15)6-12(10)17-13(16)11(9)5-7/h1-6,14-15H
Clave InChI
RIUPLDUFZCXCHM-UHFFFAOYSA-N
Aplicación
Urolithin A has been used:
- to test its antileukemic activities on leukemic cell lines by in vitro cell proliferation assay
- as a mitophagy activator to study the effect of phosphoglycerate mutase 5 (PGAM5) expression on mitophagic cell death during ischemia-reperfusion (I/R) injury
- to study its inhibitory effect on epithelial-to-mesenchymal transition (EMT) in lung cancer cells via P53-Mdm2-Snail pathway
- to study its effects on streptozotocin-induced diabetic cardiomyopathy in rats by activating sirtuin 1/silent mating type information regulation 2 homolog 1 (SIRT1) signaling
Acciones bioquímicas o fisiológicas
Urolithin A is a natural product with antiproliferative and antioxidant activity.
Urolithin A is a natural product with antiproliferative and antioxidant activity. Urolithin A is formed by metabolism from polyphenols found in some nuts and fruits, particularly pomegranates. Urolithin A has been shown to cross the blood brain barrier, and may have neuroprotective effects against Alzheimer′s Disease.
Urolithin A is the most studied urolithin with anti-inflammatory and anti-obesity properties. It may also prevent the progression of various cancer types including colon, prostate, and bladder cancer by downregulating several oncogenes such as the mammalian target of rapamycin (mTOR) and Kirsten rat sarcoma viral oncogene(K-Ras), upregulating tumor suppressor genes such as p53 and epidermal growth factor receptor (EGFR) in various tumor pathways.
Palabra de señalización
Warning
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Eye Irrit. 2 - Skin Irrit. 2
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Elija entre una de las versiones más recientes:
Certificados de análisis (COA)
Lot/Batch Number
¿No ve la versión correcta?
Si necesita una versión concreta, puede buscar un certificado específico por el número de lote.
¿Ya tiene este producto?
Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Los clientes también vieron
Yun Wang et al.
Toxicology in vitro : an international journal published in association with BIBRA, 29(5), 1107-1115 (2015-04-26)
The intestinal metabolites of ellagic acid (EA), urolithins are known to effectively inhibit cancer cell proliferation. This study investigates antiproliferative and antioxidant effects of urolithin A (UA) on cell survival of the HepG2 hepatic carcinomas cell line. The antiproliferative effects
Abdulaziz Musa Alzahrani et al.
International journal of molecular sciences, 22(11) (2021-06-03)
Leukemia is persistently a significant cause of illness and mortality worldwide. Urolithins, metabolites of ellagic acid and ellagitannins produced by gut microbiota, showed better bioactive compounds liable for the health benefits exerted by ellagic acid and ellagitannins containing pomegranate and
Gadah Albasher et al.
Saudi journal of biological sciences, 29(2), 1210-1220 (2022-03-05)
This study examined the cardiac anti-cardiomyopathy (DC) protective effect of urolithin A in streptozotocin (STZ)-treated rats and investigated if this protection involves activation of SIRT1 signaling. Diabetes was induced first STZ (65 mg/kg, i.p.) before starting the experiments. Adult male rats
Antonio González-Sarrías et al.
European journal of nutrition, 56(2), 831-841 (2015-12-19)
Urolithins, metabolites produced by the gut microbiota from ellagic acid, have been acknowledged with cancer chemopreventive activity. Although urolithin A (Uro-A) has been reported to be the most active one, 10-50 % of humans can also produce the isomer isourolithin A
Sheng-Long Ding et al.
Journal of inflammation (London, England), 17, 13-13 (2020-03-27)
Osteoarthritis (OA) is characterized by inflammation and extracellular matrix (ECM) degradation and is one of the most common chronic degenerative joint diseases that causes pain and disability in adults. Urolithin A (UA) has been widely reported for its anti-inflammatory properties
Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.
Póngase en contacto con el Servicio técnico