SML0061

SAHA

≥98% (HPLC), powder, HDAC inhibitor

• Sinónimos: N-hydroxy-N′-phenyl-octanediamide, Suberoylanilide hydroxamic acid, Vorinostat
• Fórmula empírica (notación de Hill): C₁₄H₂₀N₂O₃
• Número CAS: 149647-78-9
• Peso molecular: 264.32
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825127
• NACRES: NA.77
• MDL number: MFCD00945317
• Assay: ≥98% (HPLC)
• Form: powder

Propiedades

• Nombre del producto: SAHA, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to tan
• solubility: DMSO: ≥15 mg/mL
• shipped in: wet ice
• storage temp.: −20°C
• SMILES string: ONC(=O)CCCCCCC(=O)Nc1ccccc1
• InChI: 1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)
• InChI key: WAEXFXRVDQXREF-UHFFFAOYSA-N
• Gene Information: human ... HDAC1(3065), HDAC2(3066), HDAC3(8841), HDAC6(10013)

Descripción

Application

SAHA may be used to study gene regulation, transcription regulation and cell signaling.

Biochem/physiol Actions

Potent, reversible pan-histone deacetylase (HDAC) inhibitor.

Vorinostat or suberoylanilide hydroxamic acid (SAHA) is a potent, reversible pan-histone deacetylase (HDAC) inhibitor. It inhibits both class I and class II HDACs, altering gene transcription and inducing cell cycle arrest and/or apoptosis in a wide variety of transformed cells.

SAHA or Vorinostat facilitates the transcription of genes that result in apoptosis, differentiation and growth arrest. It has been observed to give beneficial results in lymphoma but not in solid tumors.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Información de seguridad

• Pictogramas: GHS08
• Palabra de advertencia: Danger
• Códigos de peligro: H341,H360
• Indicaciones de precaución: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Muta. 2 - Repr. 1A
• Clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable