SAB4300464

Anti-APP (Ab-668) antibody produced in rabbit

affinity isolated antibody

• Sinónimos: Anti-AAA antibody produced in rabbit, Anti-ABETA antibody produced in rabbit, Anti-ABPP antibody produced in rabbit, Anti-AD1 antibody produced in rabbit, Anti-amyloid beta (A4) precursor protein antibody produced in rabbit
• UNSPSC Code: 12352203
• NACRES: NA.41

Propiedades

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: 100-140 kDa
• species reactivity: human, mouse, rat
• concentration: 1 mg/mL
• technique(s): indirect immunofluorescence: 1:100-1:200; western blot: 1:500-1:1000
• isotype: IgG
• immunogen sequence: ( A-V-T-P-E)
• NCBI accession no.: NP_000475.1
• UniProt accession no.: P05067
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... APP(351)

Descripción

General description

Amyloid β precursor protein (APP) is a type I transmembrane glycoprotein. The APP gene is mapped to human chromosome 21q21.3 and encodes various isoforms due to alternative splicing events. APP displays the ubiquitous expression, although, high levels are observed in the brain. It comprises a large ectodomain, short cytoplasmic tail, E1, and E2 domains. The E1 domain harbors a growth factor-like domain (GFLD) and a copper-binding domain (CuBD).

Immunogen

Peptide sequence around aa. 666-670 ( A-V-T-P-E ), according to the protein APP.

Application

Anti-APP (Ab-668) antibody produced in rabbit has been used in:

• immunohistochemistry
• immunolabeling
• western blotting
• immunoprecipitation

Biochem/physiol Actions

Amyloid β precursor protein (APP) serves as a precursor of amyloid β (Aβ) peptide. It participates in synaptic function, trans-cellular synaptic adhesion, and in the anterograde transport of the virus.

Features and Benefits

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Target description

APP encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable