S0383

Sulfameter

• Sinónimos: 5-Methoxysulfadiazine, N¹-(5-Methoxypyrimidin-2-yl)sulfanilamide, Sulfamethoxydiazine
• Fórmula empírica (notación de Hill): C₁₁H₁₂N₄O₃S
• Número de CAS: 651-06-9
• Peso molecular: 280.30
• Beilstein: 621130
• Número CE: 211-480-8
• Número MDL: MFCD00006067
• Código UNSPSC: 51283913
• ID de la sustancia en PubChem: 24899422
• NACRES: NA.85

Propiedades

• Formulario: powder
• Nivel de calidad: 200
• condiciones de almacenamiento: (Keep container tightly closed in a dry and well-ventilated place. Light sensitive.)
• color: white to faint yellow
• espectro de actividad antibiótica: Gram-negative bacteria; Gram-positive bacteria; mycobacteria; parasites
• Modo de acción: enzyme | inhibits
• temp. de almacenamiento: 2-8°C
• cadena SMILES: COc1cnc(NS(=O)(=O)c2ccc(N)cc2)nc1
• InChI: 1S/C11H12N4O3S/c1-18-9-6-13-11(14-7-9)15-19(16,17)10-4-2-8(12)3-5-10/h2-7H,12H2,1H3,(H,13,14,15)
• Clave InChI: GPTONYMQFTZPKC-UHFFFAOYSA-N

Descripción

Descripción general

Chemical structure: sulfonamide

Aplicación

Sulfameter is a sulfonamide antibiotic used as a leprostatic agent and to treat urinary tract infections. It has been investigated as a potential therapy for chloroquine-resistant malaria during pregnancy.

Acciones bioquímicas o fisiológicas

Sulfameter is a sulfonamide antibiotic. Sulfonamides block the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfonamides are competitive inhibitors of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid. Sulfameter is a dihydrofolate reductase (DHFR) inhibitor. Sulfonamides are active against Gram positive bacteria and Gram negative bacteria. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.

Otras notas

Keep container tightly closed in a dry and well-ventilated place. Light sensitive.

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H315,H319,H335
• Consejos de prudencia: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Clasificaciones de peligro: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órganos de actuación: Respiratory system
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Gloves