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S0149

Sigma-Aldrich

Streptolysin O from Streptococcus pyogenes

γ-irradiated

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About This Item

Número de CAS:
98072-47-0
EC Number:
308-500-3
MDL number:
MFCD00132389
UNSPSC Code:
12352200
NACRES:
NA.77

biological source

Streptococcus pyogenes

Quality Level

200

sterility

γ-irradiated

form

lyophilized powder

application(s)

cell analysis

storage temp.

2-8°C

Gene Information

Streptococcus pyogenes ... slo(900490)

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Application

Streptolysin O from Streptococcus pyogenes has been used in streptolysin O (SLO) permeabilization. It has also been used to evaluate the barrier integrity and cytotoxicity of caco-2 and T84 IEC polarized monolayers.
Permeabilizes membranes to permit cellular uptake of large or charged molecules.

Biochem/physiol Actions

Streptolysin O (SLO), obtained from Streptococcus pyogenes has the capability to block osteoclastogenesis, induced by receptor activator of nuclear factor κ-Β ligand (RANK) through the NF-κB signaling pathway. Streptococcus pyogenes (GAS) is a bacterial strain that results in bacterial arthritis, osteomyelitis and implant infections.
Thiol-activated toxin that permeabilizes animal cell membranes. The protein binds as a monomer to membrane cholesterol and subsequently polymerizes into large arc- and ring-shaped structures surrounding pores of >12 nm.

Unit Definition

One unit will cause 50% lysis of 2% red blood cell suspensions in phosphate buffered saline, pH 7.4, after incubation at 37 °C for 30 min.

Preparation Note

Prepared from S 5265

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 1 Oral

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Extended exposure duration of cultured intestinal epithelial cell monolayers in characterizing hazardous and non-hazardous proteins
Zimmermann C, et al.
Food And Chemical Toxicology, 115(4), 451-459 (2018)
Elevated levels of StAR-related lipid transfer protein 3 alter cholesterol balance and adhesiveness of breast cancer cells: potential mechanisms contributing to progression of HER2-positive breast cancers
Vassilev B, et al.
The American Journal of Pathology, 185(4), 987-1000 (2015)
Streptolysin O derived from Streptococcus pyogenes inhibits RANKL-induced osteoclastogenesis through the NF-kappaB signaling pathway
Yi J, et al.
Molecular Medicine Reports (2018)
Quan D Zhou et al.
Nature immunology, 21(7), 746-755 (2020-06-10)
Plasma membranes of animal cells are enriched for cholesterol. Cholesterol-dependent cytolysins (CDCs) are pore-forming toxins secreted by bacteria that target membrane cholesterol for their effector function. Phagocytes are essential for clearance of CDC-producing bacteria; however, the mechanisms by which these
Mingqun Lin et al.
Autophagy, 12(11), 2145-2166 (2016-11-02)
Ehrlichia chaffeensis is an obligatory intracellular bacterium that causes a potentially fatal emerging zoonosis, human monocytic ehrlichiosis. E. chaffeensis has a limited capacity for biosynthesis and metabolism and thus depends mostly on host-synthesized nutrients for growth. Although the host cell

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