RAB1317
Human Cathepsin D ELISA
for serum, plasma and cell culture supernatants
Sinónimos:
Cathepsin D
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About This Item
Código UNSPSC:
41116158
NACRES:
NA.32
Productos recomendados
reactividad de especies
human
envase
kit of 96 wells (12 strips x 8 wells)
técnicas
ELISA: suitable
entrada
sample type cell culture supernatant(s)
sample type plasma
sample type serum
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 50 pg/mL
standard curve range: 0.049-12 ng/mL
método de detección
colorimetric
Condiciones de envío
wet ice
temp. de almacenamiento
−20°C
Información sobre el gen
human ... CTSD(1509)
Descripción general
This ELISA antibody pair detects human Cathepsin D. Other species not yet determined.
Aplicación
For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.
Please refer to the attached Protocolfor details.
Acciones bioquímicas o fisiológicas
Cathepsin D encoded by CTSD gene, is an aspartyl protease, plays a major role in degradation of intracellular and endocytosed protein, for maintenance of tissue homeostasis and metabolism. Cathepsin D works as an endopeptidase in the acidic environment of lysosomes. Cathepsin D is part of signal transduction and a potential target for various cancer. Increased levels of Cathepsin D is associated with type 2 diabetes. Cathepsin D regulates sphingolipid metabolism and cholesterol trafficking. Genetic variations in Cathepsin D gene is a risk factor for Alzheimer′s disease and neuronal ceroid lipofuscinosis. Cathepsin D is a key marker in atherosclerosis and level of expression is increased in atherosclerotic lesions. Cathepsin D regulates the degradation of advanced glycation end products (AGEs) and impaired activity of cathepsin D results in accumulation of AGEs in photoaged skin. Increased plasma concentration of Cathepsin D causes non-alcoholic steatohepatitis (NASH) leading to hepatic lipid accumulation and inflammation.
Otras notas
A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.
Palabra de señalización
Warning
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Met. Corr. 1
Código de clase de almacenamiento
8A - Combustible corrosive hazardous materials
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Cathepsin D, a lysosomal protease, regulates ABCA1-mediated lipid efflux
Haidar B, et al.
The Journal of Biological Chemistry, 281(52), 39971-39981 (2006)
Correlation between cathepsin D serum concentration and carotid intima-media thickness in hemodialysis patients
Moallem SA, et al.
International Urology and Nephrology, 43(3), 841-848 (2011)
Plasma cathepsin D correlates with histological classifications of fatty liver disease in adults and responds to intervention
Walenbergh SMA, et al.
Scientific Reports, 6(3), 38278-38278 (2016)
Increased Cathepsin D Correlates with Clinical Parameters in Newly Diagnosed Type 2 Diabetes
Liu L, et al.
Disease Markers, 2017 (2017)
Cathepsin D contributes to the accumulation of advanced glycation end products during photoaging
Xu X, et al.
Journal of Dermatological Science, 90(3), 263-275 (2018)
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