P8887

5α-Pregnan-3α-ol-20-one

solid

• Sinónimos: 3α-Hydroxy-5α-pregnan-20-one, 3α-OH-DHP, Allopregnan-3α-ol-20-one, Allopregnanolone, Brexanolone
• Fórmula empírica (notación de Hill): C₂₁H₃₄O₂
• Número de CAS: 516-54-1
• Peso molecular: 318.49
• Beilstein: 3211363
• Número MDL: MFCD00003677
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24278659
• NACRES: NA.77

Propiedades

• Formulario: solid
• Nivel de calidad: 200
• color: white
• solubilidad: DMSO: 5 mg/mL; methanol: soluble
• cadena SMILES: [H][C@@]12CC[C@@]3([H])[C@]4([H])CC[C@H](C(C)=O)[C@@]4(C)CC[C@]3([H])[C@@]1(C)CC[C@@H](O)C2
• InChI: 1S/C21H34O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h14-19,23H,4-12H2,1-3H3/t14-,15+,16-,17+,18-,19-,20-,21+/m0/s1
• Clave InChI: AURFZBICLPNKBZ-SYBPFIFISA-N
• Información sobre el gen: human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562) , GABRD(2563) , GABRE(2564) , GABRG1(2565) , GABRG2(2566) , GABRG3(2567) , GABRP(2568) , GABRQ(55879) ; mouse ... Gabrg2(14406) ; rat ... Gabra1(29705) , Gabra2(29706) , Gabrg2(29709)

Descripción

Aplicación

5α-Pregnan-3α-ol-20-one has been used:

• as an allosteric modulator of GABAA receptors in mice
• a neuroprotective steroid in transgenic mice
• a neurosteroid

Acciones bioquímicas o fisiológicas

5α-Pregnan-3α-ol-20-one is a positive allosteric modulator of γ-aminobutyric acid (GABA) A receptor (GABAA). It is also called pregnan and during pregnancy it modulates the atrial volume receptors transducer properties. During estrus cycle, 5α-Pregnan-3α-ol-20-one or allopregnanolone levels changes in hypothalamus. It is present in high levels post adrenalectomy and gonadectomy.

Características y beneficios

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)