O2875

Orotic acid potassium salt

≥98%

• Sinónimos: 6-Carboxy-2,4-dihydroxypyrimidine, Uracil-6-carboxylic acid
• Fórmula lineal: C₅H₃N₂O₄K
• Número CAS: 24598-73-0
• Peso molecular: 194.19
• NACRES: NA.51
• PubChem Substance ID: 24897970
• UNSPSC Code: 41106305
• EC Number: 246-341-0
• MDL number: MFCD00039118
• Assay: ≥98%
• Form: powder
• Solubility: 1 M NaOH: 25 mg/mL, clear to slightly hazy, colorless to faintly yellow

Propiedades

• Quality Segment: 200
• assay: ≥98%
• form: powder
• solubility: 1 M NaOH: 25 mg/mL, clear to slightly hazy, colorless to faintly yellow
• SMILES string: [K+].[O-]C(=O)C1=CC(=O)NC(=O)N1
• InChI: 1S/C5H4N2O4.K/c8-3-1-2(4(9)10)6-5(11)7-3;/h1H,(H,9,10)(H2,6,7,8,11);/q;+1/p-1
• InChI key: DHBUISJCVRMTAZ-UHFFFAOYSA-M

Descripción

Application

Orotic acid (OA) is an intermediate in de novo pyrimidine biosynthesis that may be used to study the specificity and kinetics of orotate phosphoribosyltransferase (OPRT) which catalyzes the reversible phosphoribosyl transfer from 5′-phospho-α-d-ribose 1′-diphosphate (PRPP) to orotic acid (OA), forming pyrophosphate and orotidine 5′-monophosphate (OMP). Orotic acid is used as a starting material for the potential commercial bioproduction of uridine 5′-monophosphate (UMP) by microbes such as Corynebacterium ammoniagenes (ATCC 6872) or Saccharomyces cerevisiae. OA may be used to study the AMPK/SREBP-1 dependent cell signaling pathway and transcription regulation mechanisms that induce hepatic lipogenesis.

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)