N4382

Nalidixic acid sodium salt

powder

• Sinónimos: 1-Ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid sodium salt
• Fórmula empírica (notación de Hill): C₁₂H₁₁N₂NaO₃
• Número de CAS: 3374-05-8
• Peso molecular: 254.22
• Beilstein: 3580062
• Número CE: 222-159-7
• Número MDL: MFCD00064376
• Código UNSPSC: 12352106
• ID de la sustancia en PubChem: 24278589
• NACRES: NA.77

Propiedades

• Formulario: powder
• Nivel de calidad: 200
• espectro de actividad antibiótica: Gram-negative bacteria; Gram-positive bacteria
• Modo de acción: DNA synthesis | interferes; enzyme | inhibits
• emisor: Sanofi Aventis
• cadena SMILES: [Na+].CCN1C=C(C([O-])=O)C(=O)c2ccc(C)nc12
• InChI: 1S/C12H12N2O3.Na/c1-3-14-6-9(12(16)17)10(15)8-5-4-7(2)13-11(8)14;/h4-6H,3H2,1-2H3,(H,16,17);/q;+1/p-1
• Clave InChI: ROKRAUFZFDQWLE-UHFFFAOYSA-M

Descripción

Descripción general

Chemical structure: quinolone

Nalidixic acid is a quinolone and can block the activity of bacterial topoisomerase type II enzyme, thereby stopping bacterial replication. It is a potential antibacterial agent against Gram-negative bacteria than Gram-positive bacteria. Nalidixic acid has been studied in the management of urinary tract infections.

Aplicación

Nalidixicacid has been used to treat the bacterial cultures to study itsresistance on Salmonella enterica and SalmonellaTyphimurium.

Acciones bioquímicas o fisiológicas

Nalidixic acid sodium salt is an inhibitor of bacterial DNA polymerase (DNA gyrase) and avian myeloblastoma virus reverse transcriptase. Inhibits nucleic acid and protein synthesis in Saccharomyces cerevisiae.

Características y beneficios

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información de seguridad

• Pictogramas: GHS08,GHS07
• Palabra de señalización: Warning
• Frases de peligro: H302,H351
• Consejos de prudencia: P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405
• Clasificaciones de peligro: Acute Tox. 4 Oral - Carc. 2
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Faceshields, Gloves