N1538
Nobiletin
≥97%
Sinónimos:
3′, 4′, 5, 6, 7, 8-Hexamethoxyflavone
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About This Item
Fórmula empírica (notación de Hill):
C21H22O8
Número de CAS:
Peso molecular:
402.39
Beilstein:
360887
Número MDL:
Código UNSPSC:
12352205
ID de la sustancia en PubChem:
NACRES:
NA.25
Productos recomendados
Ensayo
≥97%
Formulario
powder
temp. de almacenamiento
−20°C
cadena SMILES
COc1ccc(cc1OC)C2=CC(=O)c3c(OC)c(OC)c(OC)c(OC)c3O2
InChI
1S/C21H22O8/c1-23-13-8-7-11(9-15(13)24-2)14-10-12(22)16-17(25-3)19(26-4)21(28-6)20(27-5)18(16)29-14/h7-10H,1-6H3
Clave InChI
MRIAQLRQZPPODS-UHFFFAOYSA-N
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Aplicación
- Nobiletin as a novel agent to enhance porcine in vitro embryo development and quality: This study explores the potential of nobiletin to improve embryo development and quality in porcine models, providing insights into its applications in reproductive biotechnology and animal science (Cajas YN, Martinez-Serrano CA, 2024 Apr 22) (source).
- Nobiletin alleviates cisplatin-induced ototoxicity: Research indicates that nobiletin can mitigate the ototoxic effects of cisplatin chemotherapy by activating autophagy and inhibiting ferroptosis, suggesting a new therapeutic avenue for protecting auditory health during cancer treatment (Song W, Lu Z, 2024 Apr 3) (source).
- Nobiletin targets SREBP1/ACLY to induce autophagy-dependent cell death of gastric cancer cells: This study reveals that nobiletin promotes autophagy-dependent cell death in gastric cancer cells by targeting the SREBP1/ACLY axis within the PI3K/Akt/mTOR signaling pathway, proposing a novel anticancer strategy (Chen M, Sun Q, 2024 Jun) (source).
- Recent advances in the therapeutic potential of nobiletin against respiratory diseases: A comprehensive review on the therapeutic applications of nobiletin in treating respiratory diseases, emphasizing its anti-inflammatory and antioxidant properties as mechanisms for intervention (Qin Y, Li J, 2024 Jun) (source).
Acciones bioquímicas o fisiológicas
Nobiletin suppresses the expression of matrix metalloproteinases 1, 3 and 9, which participate in the break down of the extracellular matrix during tumor metastasis. Nobiletin is also involved in the increased expression of tissue inhibitor of matrix metalloproteinase 1 further preventing extracellular matrix degradation during tumor invasion. This bioflavonoid is believed to achieve both of these functions by disrupting the signal transduction pathway of Ras-Raf-MEK.
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Nobiletin, a citrus flavonoid isolated from tangerines, alters ion transport functions in intestinal epithelia, and has antagonistic effects on eosinophilic airway inflammation of asthmatic rats. The present study examined the effects of nobiletin on basal short-circuit current (I(SC)) in a
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Inhibiting microglial activation-mediated neuroinflammation has become a convincing target for the development of functional foods to treat neurodegenerative diseases. Tangerine peel (Citri reticulatae pericarpium) has potent anti-inflammatory capacity; however, its anti-neuroinflammatory capacity and the corresponding active compounds remain unclear. To
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