I1771

Interleukin-13 human

≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

• Sinónimos: IL-13
• Número de CAS: 148157-34-0
• Número MDL: MFCD00212209
• Código UNSPSC: 12352202
• NACRES: NA.32

Propiedades

• origen biológico: human
• Nivel de calidad: 200
• recombinante: expressed in E. coli
• Ensayo: ≥97% (SDS-PAGE)
• Formulario: lyophilized powder
• potencia: <10.000 ng/mL ED₅₀
• mol peso: 12 kDa
• envase: pkg of 10 μg
• técnicas: cell culture | mammalian: suitable
• impurezas: endotoxin, tested
• color: white
• Nº de acceso UniProt: P35225
• temp. de almacenamiento: −20°C
• Información sobre el gen: human ... IL13(3596)

Descripción

Acciones bioquímicas o fisiológicas

IL-13 is known to be overexpressed in glioblastoma tumors and cell lines. Elevated IL-13 expression is also observed in parasitic infections. It stimulates fibrosis in many infectious diseases, and acts as a profibrogenic factor.

Interleukin-13 is a pleiotropic cytokine produced by activated Th2 cells in the mouse and human. IL-13 is secreted mainly as an unglycosylated protein of 132 amino acids with a molecular weight of 10,000 daltons. A 4.3kb DNA fragment of the mouse IL-13 gene was sequenced and occurs as a single copy mapping a chromosome 11. In the human, a 4.6 kb DNA segment of the IL-13 gene occurs as a single copy and maps to chromosome 5. IL-13 induces B cell proliferation and also induces IgE switching. The proliferative activity of human and mouse IL-13 products are tested in culture using the human erythroleukemic cell line TF-1.

Forma física

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 250 μg BSA.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)