H2292

Histone H3.1 human

• Sinónimos: Histone, Human
• Número CAS: 1523001-32-2
• NACRES: NA.25
• UNSPSC Code: 12352202
• Form: liquid
• Biological source: human
• Recombinant: expressed in E. coli

Propiedades

• biological source: human
• Quality Segment: 200
• recombinant: expressed in E. coli
• form: liquid
• concentration: 1 mg/mL
• technique(s): MALDI-TOF: suitable
• UniProt accession no.: P68431
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: human ... H3C1(8350)

Descripción

General description

Histone H3.1 is a histone H3 variant.[1] It differs from H3.2 with residue 96 being a cysteine instead of serine.[2] H3.1 is a replication-dependent histone and is a component of nucleosomes during the S-phase.[3]

Application

Histone H3.1 human has been used in in vitro Schizosaccharomyces pombe Set7 histone methyltransferase assay for matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF) studies.[4]

Biochem/physiol Actions

Histone H3.1 human (H3.1) undergoes a majority of post-translational modification especially acetylation and demethylation in lysine 14 and 9 respectively.[1] During differentiation, the levels of H3.1 transcripts decrease as cell division slows down.[2] The incorporation of H3.1 into chromatin is mediated by a chaperone, chromatin assembly factor (CAF-1).[1] A transversion mutation in the H3.1 may be implicated in glioma.[3]

Physical form

Supplied as 1 mg/mL in 20 mM NaPO₄, pH 7.0, 0.3 M NaCl, 1 mM EDTA, and 1 mM DTT.

Información de seguridad

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• pcodes: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2
• Clase de almacenamiento: 11 - Combustible Solids