The best practice for item H0915, Hydroxychloroquine sulfate, involves preparing the stock solution fresh before use. Although information about the stability of small molecules in solution is rare, it is generally recommended to store in PBS at -20°C. To prevent repeated freeze-thaw cycles, it is advisable to aliquot into working volumes. Additionally, the effect of storing the stock solution on compound performance should be evaluated for each specific application. When used as a cell culture supplement, the stock solution should be diluted into the culture medium immediately before use.
H0915
Sulfato de hidroxicloroquina
≥98% (HPLC), powder, anti-inflammatory
Sinónimos:
Sulfato de 7-cloro-4-[4-(N-etil-N-b-hidroxietilamino)-1-metilbutilamino]quinolina
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| Talla/SKU | Disponibilidad | Precio |
|---|---|---|
5 mg | Comprobar disponibilidad del carrito | $111.000 |
25 mg | Comprobar disponibilidad del carrito | $461.000 |
Acerca de este artículo
Fórmula empírica (notación de Hill):
C18H26ClN3O · H2SO4
Número CAS:
Peso molecular:
433.95
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
212-019-3
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
protect from light
Servicio técnico
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Permítanos ayudarleNombre del producto
Sulfato de hidroxicloroquina, ≥98% (HPLC), powder
Quality Segment
assay
≥98% (HPLC)
form
powder
storage condition
protect from light
color
white to off-white
solubility
H2O: >20 mg/mL
SMILES string
OS(O)(=O)=O.CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12
InChI
1S/C18H26ClN3O.H2O4S/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18;1-5(2,3)4/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21);(H2,1,2,3,4)
InChI key
JCBIVZZPXRZKTI-UHFFFAOYSA-N
Gene Information
human ... TLR7(51284), TLR9(54106)
Application
Hydroxychloroquine sulfate has been used:
- as an inhibitor of autophagy to treat cells for apoptosis assay to study the role of pirarubicin induced autophagy in bladder cancer cell line
- to evaluate the antiviral mechanism of hydroxychloroquine against DENV-2 (dengue virus-2) infection by immunofluorescence assay
- to inhibit lysosome fusion with the autophagosome
Biochem/physiol Actions
Hydroxychloroquine is also used for treating rheumatoid arthritis and systemic lupus erythematosus.
El sulfato de hidroxicloroquina es un antiinflamatorio (vía TNF), un antirreumático modificador de la enfermedad (DMARD) y un inhibidor de la hemo polimerasa.
El sulfato de hidroxicloroquina es un antiinflamatorio (vía TNF), un antirreumático modificador de la enfermedad (DMARD) y un inhibidor de la hemo polimerasa. Se utiliza para tratar el paludismo.
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Este artículo | |||
|---|---|---|---|
| description ≥98% (HPLC), powder | description Pharmaceutical Secondary Standard; Certified Reference Material | description analytical standard | description European Pharmacopoeia (EP) Reference Standard |
| assay ≥98% (HPLC) | assay - | assay ≥95.0% (HPLC) | assay - |
| form powder | form powder or crystals | form - | form - |
| Quality Level 100 | Quality Level 300 | Quality Level 100 | Quality Level - |
| solubility H2O: >20 mg/mL | solubility chloroform: practically insoluble, ethanol: practically insoluble, water: soluble, ether: practically insoluble | solubility - | solubility - |
| storage condition protect from light | storage condition protect from light | storage condition - | storage condition - |
| color white to off-white | color white to off-white | color white to off-white | color - |
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Palabra de advertencia
Warning
Códigos de peligro
Indicaciones de precaución
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
Clase de almacenamiento
11 - Combustible Solids
¿Qué está pasando?
WGK 3
Punto de inflamación (°F)
Not applicable
Punto de inflamación (°C)
Not applicable
EPI (equipos de protección individual)
dust mask type N95 (US), Eyeshields, Gloves
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How should stock solutions of H0915, Hydroxychloroquine sulfate, be stored after reconstituting in water or PBS?
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