G6423

Gemcitabine hydrochloride

≥98% (HPLC), powder, deoxycytidine analog

• Sinónimos: 2′-Deoxy-2′,2′-difluorocytidine; dFdC, Gemzar (Lilly), LY-188011, dFdC, dFdCyd
• Fórmula empírica (notación de Hill): C₉H₁₁F₂N₃O₄ · HCl
• Número CAS: 122111-03-9
• Peso molecular: 299.66
• UNSPSC Code: 12352200
• PubChem Substance ID: 329799951
• NACRES: NA.77
• MDL number: MFCD01735988
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated, protect from light

Propiedades

• Nombre del producto: Gemcitabine hydrochloride, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated, protect from light
• solubility: H₂O: ≥10 mg/mL
• originator: Eli Lilly
• storage temp.: room temp
• SMILES string: Cl.NC1=NC(=O)N(C=C1)[C@@H]2O[C@H](CO)[C@@H](O)C2(F)F
• InChI: 1S/C9H11F2N3O4.ClH/c10-9(11)6(16)4(3-15)18-7(9)14-2-1-5(12)13-8(14)17;/h1-2,4,6-7,15-16H,3H2,(H2,12,13,17);1H/t4-,6-,7-;/m1./s1
• InChI key: OKKDEIYWILRZIA-OSZBKLCCSA-N
• Gene Information: human ... POLA1(5422), POLA2(23649), POLD1(5424), POLD2(5425), POLD3(10714), POLD4(57804), POLE(5426), POLE2(5427), POLE3(54107), PRIM1(5557), PRIM2(5558), RRM1(6240), RRM2(6241), RRM2B(50484)

Descripción

General description

Gemcitabineis a pyrimidine nucleoside analog of deoxycytidine. It exhibits anticancereffects against various cancers.[1]

Application

Gemcitabinehydrochloride has been used as a chemotherapeutic agent to study its effects onthe human pancreatic adenocarcinoma cell line[2]It has been used as a chemotherapeutic to study its resistance inpancreatic stellate cells (PSCs)[3]It has also been used to study its effects on patient-derivedxenograft (PDX) organoids.[4]

Biochem/physiol Actions

Gemcitabine is a widely used antineoplastic agent and antimetabolite.

Gemcitabine is a widely used antitumor agents in both clinics and research labs. It is an antineoplastic agent and antimetabolite.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información de seguridad

• pictograms: GHS08
• signalword: Danger
• hcodes: H360
• pcodes: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 1B
• Clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable